biostudies-literatureUnknown10Wienecke LM<h4>Background</h4>Adults with congenital heart disease (ACHD) display changes in adaptive immunity related to early open-heart surgery and subsequent incidental thymectomy. In acquired heart failure (HF) systemic inflammation, innate and adaptive immune cells play an important role. However, cellular immune alterations of monocyte, T lymphocyte and natural killer (NK) cell subsets have not been related to HF in ACHD.<h4>Methods and results</h4>This cross-sectional study included 209 ACHD outpatients (mean age: 35.3 ± 11.0 years; NYHA class I/II/III-IV 64.1%/21.5%/14.4%; 59.8% male) and 21 healthy controls (29.8 ± 12.6 years; 47.6% male). Patients with clinical signs of infection, inflammatory diseases or malignancies were excluded. Flow cytometry of fresh whole blood revealed significantlInternational journal of cardiology. Congenital heart disease100418https://www.ebi.ac.uk/biostudies/studies/S-EPMC11657347biostudies-literatureAltered compositions of monocyte, T lymphocyte and NK cell subsets in heart failure of adult congenital heart disease.PMC11657347Westhoff-Bleck MFraccarollo DKockelmann FBauersachs JWienecke LMLemke LHGaluppo PThol JfalseAltered compositions of monocyte, T lymphocyte and NK cell subsets in heart failure of adult congenital heart disease.<h4>Background</h4>Adults with congenital heart disease (ACHD) display changes in adaptive immunity related to early open-heart surgery and subsequent incidental thymectomy. In acquired heart failure (HF) systemic inflammation, innate and adaptive immune cells play an important role. However, cellular immune alterations of monocyte, T lymphocyte and natural killer (NK) cell subsets have not been related to HF in ACHD.<h4>Methods and results</h4>This cross-sectional study included 209 ACHD outpatients (mean age: 35.3 ± 11.0 years; NYHA class I/II/III-IV 64.1%/21.5%/14.4%; 59.8% male) and 21 healthy controls (29.8 ± 12.6 years; 47.6% male). Patients with clinical signs of infection, inflammatory diseases or malignancies were excluded. Flow cytometry of fresh whole blood revealed significantl2022-01-01T00:00:00Z2022 Dec2025-04-04T01:09:00.575Z2025-04-04T01:09:00.575ZS-EPMC116573473971359010.1016/j.ijcchd.2022.100418