{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Su YT"],"funding":["Ministry of Science and Technology","China Medical University, Taiwan and China Medical University Hospital HsinChu Branch","China Medical University, Taiwan","Asia University Hospital","National Health Research Institutes","National Science and Technology Council","China Medical University Hospital"],"pagination":["e70277"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11657596"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(24)"],"pubmed_abstract":["Lipid reprogramming in carcinoma is reported to have a role in carcinogenesis, prognosis and therapy response. The lipid reprogramming could be contributed by either autonomous or nonautonomous resources. Since the nonautonomous lipid resources contributed by lipoproteins and their receptors have been reported in epithelial ovarian cancer (EOC), the impact of autonomous lipid metabolites was unknown. This report revealed a unique lipid class, ether-linked phosphatidyl-ethanolamine (PE O-), which enhances chemo-insensitivity and progression in EOC and potentially cross carcinomas. Analysis of CCLEC/GDSCC database and in-house cell line lipidomes identified PE O- as the major lipid associated with cisplatin/paclitaxel sensitivity. In the testing of PE O- effect on cancer phenotypes, it enhan"],"journal":["Journal of cellular and molecular medicine"],"pubmed_title":["Ether-Linked Glycerophospholipids Are Potential Chemo-Desensitisers and Are Associated With Overall Survival in Carcinoma Patients."],"pmcid":["PMC11657596"],"funding_grant_id":["DMR-113-081","DMR-114-111","AUH-11251003","DMR-112-098","NHRI-EX112-11110BI","DMR-113-117","CMUHCH-CMU-113-014","NSTC113-2320-B-039-061-MY3","CMU112-MF-45","DMR-111-118","MOST 111-2320-B-039-011-","NSTC 112-2320-B-039-005","AUH-11151021","CMU111-MF-41","CMU109-MF-26","MOST 111-2314-B-039-062-MY3"],"pubmed_authors":["Hung YC","Lin JY","Yu YC","Yang JC","Chen L","Lin WJ","Ma WL","Chang WC","Su YT","Cheng WC"],"additional_accession":[]},"is_claimable":false,"name":"Ether-Linked Glycerophospholipids Are Potential Chemo-Desensitisers and Are Associated With Overall Survival in Carcinoma Patients.","description":"Lipid reprogramming in carcinoma is reported to have a role in carcinogenesis, prognosis and therapy response. The lipid reprogramming could be contributed by either autonomous or nonautonomous resources. Since the nonautonomous lipid resources contributed by lipoproteins and their receptors have been reported in epithelial ovarian cancer (EOC), the impact of autonomous lipid metabolites was unknown. This report revealed a unique lipid class, ether-linked phosphatidyl-ethanolamine (PE O-), which enhances chemo-insensitivity and progression in EOC and potentially cross carcinomas. Analysis of CCLEC/GDSCC database and in-house cell line lipidomes identified PE O- as the major lipid associated with cisplatin/paclitaxel sensitivity. In the testing of PE O- effect on cancer phenotypes, it enhan","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-27T00:31:34.27Z","creation":"2025-04-06T17:52:09.188Z"},"accession":"S-EPMC11657596","cross_references":{"pubmed":["39700026"],"doi":["10.1111/jcmm.70277"]}}