{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen J"],"funding":["Jiangxi Province Traditional Chinese Medicine Young Chinese Backbone Talent Training Project","Jiangxi Provincial Administration of Traditional Chinese Medicine Key Research Laboratory on the Fundamentals of Chinese Medicine Evidence","Jiangxi University of Traditional Chinese Medicine School-level Science and Technology Innovation Team"],"pagination":["297"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11657705"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Objectives
To assess the association between thyroid dysfunction and diabetic retinopathy (DR), a two-sample bidirectional Mendelian randomization (MR) study utilizing the Genome-wide Association Study (GWAS) database was conducted to investigate the causal relationship between these two variables.Methods
In this study, GWAS of 48,328,151 single nucleotide polymorphisms(SNP) in the European population from the IEU open GWAS database were utilized as genetic tools for investigating thyroid dysfunction. The total sample size for the study on hyperthyroidism was 460,499 (case group: 3557; control group: 456,942). The total sample size for hypothyroidism was 410,141 (case group: 30,155; control group: 37,986). In addition, the data on DR were extracted from the FinnGen Biobank,"],"journal":["Diabetology & metabolic syndrome"],"pubmed_title":["Association between thyroid dysfunction and diabetic retinopathy: a two-sample bidirectional Mendelian randomization study."],"pmcid":["PMC11657705"],"funding_grant_id":["Gan TCM Comprehensive Word [2020] No.9","Gan TCM Science and Education Word [2022] No.8-4","CXTD22016"],"pubmed_authors":["Cheng S","Xiong J","Zhang F","Pan W","Chen J"],"additional_accession":[]},"is_claimable":false,"name":"Association between thyroid dysfunction and diabetic retinopathy: a two-sample bidirectional Mendelian randomization study.","description":"Objectives
To assess the association between thyroid dysfunction and diabetic retinopathy (DR), a two-sample bidirectional Mendelian randomization (MR) study utilizing the Genome-wide Association Study (GWAS) database was conducted to investigate the causal relationship between these two variables.Methods
In this study, GWAS of 48,328,151 single nucleotide polymorphisms(SNP) in the European population from the IEU open GWAS database were utilized as genetic tools for investigating thyroid dysfunction. The total sample size for the study on hyperthyroidism was 460,499 (case group: 3557; control group: 456,942). The total sample size for hypothyroidism was 410,141 (case group: 30,155; control group: 37,986). In addition, the data on DR were extracted from the FinnGen Biobank,","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-04T01:09:22.28Z","creation":"2025-04-04T01:09:22.28Z"},"accession":"S-EPMC11657705","cross_references":{"pubmed":["39696372"],"doi":["10.1186/s13098-024-01552-0"]}}