{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(1)"],"submitter":["Lerer L"],"pubmed_abstract":["There is growing interest in the therapeutic potential of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) for psychiatric disorders. Although 5-MeO-DMT can be chemically synthesized, the parotoid gland secretions of <i>Incilius alvarius</i> (also known as the Colorado River or Sonoran Desert toad) contain 5-MeO-DMT and other molecules including bufotenine, bufagenins, bufotoxins, and indole alkylamines that may have individual clinical utility or act as <i>entourage molecules</i> to enhance the activity of 5-MeO-DMT. <i>I. alvarius</i> is currently under severe ecological pressure due to demand for natural 5-MeO-DMT and habitat loss. We established a cell line from tissue obtained by wedge biopsy of the <i>I. alvarius</i> parotoid gland and confirmed the cell-based biosynthesis of 5-MeO-DMT b"],"journal":["Psychedelic medicine (New Rochelle, N.Y.)"],"pagination":["38-42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11658656"],"repository":["biostudies-literature"],"pubmed_title":["&lt;i&gt;Incilius alvarius&lt;/i&gt; Cell-Based Synthesis of 5-Methoxy-N,N-Dimethyltryptamine."],"pmcid":["PMC11658656"],"pubmed_authors":["Lerer B","Reynolds E","Blakolmer K","Lerer L","Varia J"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Incilius alvarius&lt;/i&gt; Cell-Based Synthesis of 5-Methoxy-N,N-Dimethyltryptamine.","description":"There is growing interest in the therapeutic potential of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) for psychiatric disorders. Although 5-MeO-DMT can be chemically synthesized, the parotoid gland secretions of <i>Incilius alvarius</i> (also known as the Colorado River or Sonoran Desert toad) contain 5-MeO-DMT and other molecules including bufotenine, bufagenins, bufotoxins, and indole alkylamines that may have individual clinical utility or act as <i>entourage molecules</i> to enhance the activity of 5-MeO-DMT. <i>I. alvarius</i> is currently under severe ecological pressure due to demand for natural 5-MeO-DMT and habitat loss. We established a cell line from tissue obtained by wedge biopsy of the <i>I. alvarius</i> parotoid gland and confirmed the cell-based biosynthesis of 5-MeO-DMT b","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2025-04-22T18:48:21.118Z","creation":"2025-04-06T02:38:20.179Z"},"accession":"S-EPMC11658656","cross_references":{"pubmed":["40047010"],"doi":["10.1089/psymed.2022.0001"]}}