biostudies-literatureJeppesen DKNicholas Tierney GI Cancer Memorial FundNational Cancer InstituteNCI NIH HHSjcs260201https://www.ebi.ac.uk/biostudies/studies/S-EPMC11658686biostudies-literatureUnknown137(23)Cells can communicate with neighboring and more distant cells by secretion of extracellular vesicles (EVs). EVs are lipid bilayer membrane-bound structures that can be packaged with proteins, nucleic acids and lipids that mediate cell-cell signaling. EVs are increasingly recognized to play numerous important roles in both normal physiological processes and pathological conditions. Steady progress in the field has uncovered a great diversity and heterogeneity of distinct vesicle types that appear to be secreted from most, if not all, cell types. Recently, it has become apparent that cells also release non-vesicular extracellular nanoparticles (NVEPs), including the newly discovered exomeres and supermeres. In this Cell Science at a Glance article and the accompanying poster, we provide an oJournal of cell scienceExtracellular vesicles and nanoparticles at a glance.PMC11658686U2CCA233291P50CA236733P01 CA229123P50 CA236733U2C CA233291R35CA197570R35 CA197570P01CA229123Coffey RJJeppesen DKZhang QfalseExtracellular vesicles and nanoparticles at a glance.Cells can communicate with neighboring and more distant cells by secretion of extracellular vesicles (EVs). EVs are lipid bilayer membrane-bound structures that can be packaged with proteins, nucleic acids and lipids that mediate cell-cell signaling. EVs are increasingly recognized to play numerous important roles in both normal physiological processes and pathological conditions. Steady progress in the field has uncovered a great diversity and heterogeneity of distinct vesicle types that appear to be secreted from most, if not all, cell types. Recently, it has become apparent that cells also release non-vesicular extracellular nanoparticles (NVEPs), including the newly discovered exomeres and supermeres. In this Cell Science at a Glance article and the accompanying poster, we provide an o2024-01-01T00:00:00Z2024 Dec2026-05-23T03:20:26.766Z2026-05-23T03:08:45.01ZS-EPMC116586863964119810.1242/jcs.260201