{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Reynolds HR"],"funding":["NCATS NIH HHS","NHLBI NIH HHS","NIH"],"pagination":["e013743"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11658795"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(12)"],"pubmed_abstract":["<h4>Background</h4>The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, type of testing used, presence and extent of prior infarction, collateral blood flow, plaque characteristics, microvascular disease, coronary vasomotor tone, and genetic factors. Among chronic coronary disease participants with site-determined moderate or severe ischemia, we investigated associations between ischemia severity on stress testing and the extent of CAD on coronary computed tomography angiography.<h4>Methods</h4>Clinically indicated stress testing included nuclear imaging, echocardiography, cardiac magnetic resonance im"],"journal":["Circulation. Cardiovascular interventions"],"pubmed_title":["Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial."],"pmcid":["PMC11658795"],"funding_grant_id":["U01HL105561","U01HL105462","U01HL105907","U01 HL105462","U01 HL105561","U01 HL105907","UL1 TR001445","U01 HL105565","U01HL105565"],"pubmed_authors":["Matar F","Desire S","Little T","Mull JA","Desimone LA","Srbinovska Kostovska E","O'Brien SM","Alexanderson Rosas E","De Rosen VL","Yun CH","Jaskowiak AJ","Nicollet E","Uchida N","Asiah Basri N","Cheong B","Santana A","Claudia M","Alfonso MA","Olsowka M","Fletcher G","Priya V","Khairuddin A","Rocco TP","Qi J","Yu Q","Fontos G","de Aveiro Morata J","Zambrano Y","Mortara A","Deedwania P","Gevorgyan R","O'Rourke D","Gulati G","Yu Z","Kaczmarska E","Witkowski A","Smith BR","Mishra S","Wald R","Gruensfelder S","Zhu B","Zarka A","Selvanayagam JB","van Vugt S","Gagne CE","Little H","Laddu AA","Faxon DP","Mishra G","Santos 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A","Venn-Edmonds C","Loh PH","Turner MC","Bridi L","Verna E","Medina Rodriguez S","Pruszczyk P","Kim A","O Kane P","Drouin K","Pejkov H","Hessian RC","Henderson R","Mendes Oliveira R","Christopher J","Stone GW","Charles T","Stankovic G","van Dongen E","Czarniak B","Ostrander A","Geng Y","Bhargava B","Cheng G","Singh Meharwal Z","de Carvalho Maffei N","Kobashigawa J","Davidson-Ray L","de Barros E Silva M","Holland K","Werner N","Webber S","Vezina DP","Eliahou L","Lane GE","Nataraj N","Felix-Stern L","Ginel Iglesias A","Genereux P","Ferket S","Dauber IM","Karlsson S","Lebioda P","Richards AJ","Madero Rovalo M","Michael S","Lorin J","Carruthers K","Wojtala E","Ouyang P","Reda H","Nishimura S","Wisniewski B","Mathus S","Park H","Konigstein M","Jakal A","Hultberg K","Wyman R","Swiatkowski A","Nugent K","Wannasopha Y","Misra A","Beaudry S","Ho J","Scaro G","Espinosa D","Portugal G","Hirsch J","Yue Z","Smigelskaite A","Canada S","Budoff MJ","Me S","Barioli A","Pucci G","Ireland KF","Yusnida I","Cauthren T","Cohen RA","Mackin A","Esposito G","Salerno WD","Loh JP","Banerjee S","El-Hajjar M","Kozlov PS","Parakh N","Figueiredo E","Oliveira NS","Schley A","El Kaffas S","Sonawane P","Anumpa J","O'Neal B","Jimenez M","Jimenez S"],"additional_accession":[]},"is_claimable":false,"name":"Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.","description":"<h4>Background</h4>The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, type of testing used, presence and extent of prior infarction, collateral blood flow, plaque characteristics, microvascular disease, coronary vasomotor tone, and genetic factors. Among chronic coronary disease participants with site-determined moderate or severe ischemia, we investigated associations between ischemia severity on stress testing and the extent of CAD on coronary computed tomography angiography.<h4>Methods</h4>Clinically indicated stress testing included nuclear imaging, echocardiography, cardiac magnetic resonance im","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-06T16:05:04.136Z","creation":"2026-06-02T03:12:01.87Z"},"accession":"S-EPMC11658795","cross_references":{"pubmed":["39689188"],"doi":["10.1161/circinterventions.123.013743","10.1161/CIRCINTERVENTIONS.123.013743"]}}