{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Spater T"],"pubmed_abstract":["<h4>Introduction</h4>Tendon injuries represent an ongoing challenge in clinical practice due to poor regenerative capacity, structure, and biomechanical function recovery of ruptured tendons. This study is focused on the assessment of a novel strategy to repair ruptured Achilles tendons in a Nude rat model using stem cell-seeded biomaterial.<h4>Methods</h4>Specifically, we have used induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) overexpressing the early tendon marker Scleraxis (SCX, iMSC<sup>SCX+</sup>, iTenocytes) in combination with an elastic collagen scaffold. Achilles tendon defects in Nude rat models were created by isolating the tendon and excising 3 mm of the midsection. The Achilles tendon defects were then repaired with iTenocyte-seeded scaffolds, uns"],"journal":["Frontiers in bioengineering and biotechnology"],"pagination":["1407729"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11658981"],"repository":["biostudies-literature"],"pubmed_title":["Collagen scaffold-seeded iTenocytes accelerate the healing and functional recovery of Achilles tendon defects in a rat model."],"pmcid":["PMC11658981"],"pubmed_authors":["Spater T","Huang D","Metzger W","Del Rio P","Shelest O","Sheyn J","Metzger M","Tawackoli W","Sheyn D","Wechsler JT","Kaneda G","Chavez M","Yu V"],"additional_accession":[]},"is_claimable":false,"name":"Collagen scaffold-seeded iTenocytes accelerate the healing and functional recovery of Achilles tendon defects in a rat model.","description":"<h4>Introduction</h4>Tendon injuries represent an ongoing challenge in clinical practice due to poor regenerative capacity, structure, and biomechanical function recovery of ruptured tendons. This study is focused on the assessment of a novel strategy to repair ruptured Achilles tendons in a Nude rat model using stem cell-seeded biomaterial.<h4>Methods</h4>Specifically, we have used induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) overexpressing the early tendon marker Scleraxis (SCX, iMSC<sup>SCX+</sup>, iTenocytes) in combination with an elastic collagen scaffold. Achilles tendon defects in Nude rat models were created by isolating the tendon and excising 3 mm of the midsection. The Achilles tendon defects were then repaired with iTenocyte-seeded scaffolds, uns","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-18T12:52:34.481Z","creation":"2025-04-06T22:16:40.749Z"},"accession":"S-EPMC11658981","cross_references":{"pubmed":["39713100"],"doi":["10.3389/fbioe.2024.1407729"]}}