{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(12)"],"submitter":["Zhao M"],"pubmed_abstract":["The behavior of an organism is influenced by the complex interplay between its brain, body and environment. Existing data-driven models focus on either the brain or the body-environment. Here we present BAAIWorm, an integrative data-driven model of Caenorhabditis elegans, which consists of two submodels: the brain model and the body-environment model. The brain model was built by multicompartment models with realistic morphology, connectome and neural population dynamics based on experimental data. Simultaneously, the body-environment model used a lifelike body and a three-dimensional physical environment. Through the closed-loop interaction between the two submodels, BAAIWorm reproduced the realistic zigzag movement toward attractors observed in C. elegans. Leveraging this model, we inves"],"journal":["Nature computational science"],"pagination":["978-990"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11659166"],"repository":["biostudies-literature"],"pubmed_title":["An integrative data-driven model simulating C. elegans brain, body and environment interactions."],"pmcid":["PMC11659166"],"pubmed_authors":["Wang N","Zhao M","Huang T","Ma L","He G","Jiang X","Ma X","Ma H","Du K"],"additional_accession":[]},"is_claimable":false,"name":"An integrative data-driven model simulating C. elegans brain, body and environment interactions.","description":"The behavior of an organism is influenced by the complex interplay between its brain, body and environment. Existing data-driven models focus on either the brain or the body-environment. Here we present BAAIWorm, an integrative data-driven model of Caenorhabditis elegans, which consists of two submodels: the brain model and the body-environment model. The brain model was built by multicompartment models with realistic morphology, connectome and neural population dynamics based on experimental data. Simultaneously, the body-environment model used a lifelike body and a three-dimensional physical environment. Through the closed-loop interaction between the two submodels, BAAIWorm reproduced the realistic zigzag movement toward attractors observed in C. elegans. Leveraging this model, we inves","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-22T10:44:39.67Z","creation":"2025-04-05T23:41:17.123Z"},"accession":"S-EPMC11659166","cross_references":{"pubmed":["39681671"],"doi":["10.1038/s43588-024-00738-w"]}}