biostudies-literatureUnknown4(12)Zhao MThe behavior of an organism is influenced by the complex interplay between its brain, body and environment. Existing data-driven models focus on either the brain or the body-environment. Here we present BAAIWorm, an integrative data-driven model of Caenorhabditis elegans, which consists of two submodels: the brain model and the body-environment model. The brain model was built by multicompartment models with realistic morphology, connectome and neural population dynamics based on experimental data. Simultaneously, the body-environment model used a lifelike body and a three-dimensional physical environment. Through the closed-loop interaction between the two submodels, BAAIWorm reproduced the realistic zigzag movement toward attractors observed in C. elegans. Leveraging this model, we invesNature computational science978-990https://www.ebi.ac.uk/biostudies/studies/S-EPMC11659166biostudies-literatureAn integrative data-driven model simulating C. elegans brain, body and environment interactions.PMC11659166Wang NZhao MHuang TMa LHe GJiang XMa XMa HDu KfalseAn integrative data-driven model simulating C. elegans brain, body and environment interactions.The behavior of an organism is influenced by the complex interplay between its brain, body and environment. Existing data-driven models focus on either the brain or the body-environment. Here we present BAAIWorm, an integrative data-driven model of Caenorhabditis elegans, which consists of two submodels: the brain model and the body-environment model. The brain model was built by multicompartment models with realistic morphology, connectome and neural population dynamics based on experimental data. Simultaneously, the body-environment model used a lifelike body and a three-dimensional physical environment. Through the closed-loop interaction between the two submodels, BAAIWorm reproduced the realistic zigzag movement toward attractors observed in C. elegans. Leveraging this model, we inves2024-01-01T00:00:00Z2024 Dec2025-04-22T10:44:39.67Z2025-04-05T23:41:17.123ZS-EPMC116591663968167110.1038/s43588-024-00738-w