biostudies-literatureUnknown14(1)Legouy C<h4>Background</h4>We aimed to investigate the association of intracranial complications diagnosed on neuroimaging with neurological outcomes of adults with severe pneumococcal meningitis.<h4>Methods</h4>We performed a retrospective multicenter study on consecutive adults diagnosed with pneumococcal meningitis requiring at least 48 h of stay in the intensive care unit (ICU) and undergoing neuroimaging, between 2005 and 2021. All neuroimaging were reanalyzed to look for intracranial complications which were categorized as (1) ischemic lesion, (2) intracranial hemorrhage (3) abscess/empyema, (4) ventriculitis, (5) cerebral venous thrombosis, (6) hydrocephalus, (7) diffuse cerebral oedema. The primary outcome was unfavorable outcome at 90 days after ICU admission, defined by a modified RankinAnnals of intensive care182https://www.ebi.ac.uk/biostudies/studies/S-EPMC11659536biostudies-literatureIntracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study.PMC11659536Aboab JGarrigues EDecavele MSonneville RTimsit JFBenghanem SRazazi KLegouy CBuiche PRambaud TEsposito-Farese MContou DCouffignal CLegriel SCornic RfalseIntracranial complications in adult patients with severe pneumococcal meningitis: a retrospective multicenter cohort study.<h4>Background</h4>We aimed to investigate the association of intracranial complications diagnosed on neuroimaging with neurological outcomes of adults with severe pneumococcal meningitis.<h4>Methods</h4>We performed a retrospective multicenter study on consecutive adults diagnosed with pneumococcal meningitis requiring at least 48 h of stay in the intensive care unit (ICU) and undergoing neuroimaging, between 2005 and 2021. All neuroimaging were reanalyzed to look for intracranial complications which were categorized as (1) ischemic lesion, (2) intracranial hemorrhage (3) abscess/empyema, (4) ventriculitis, (5) cerebral venous thrombosis, (6) hydrocephalus, (7) diffuse cerebral oedema. The primary outcome was unfavorable outcome at 90 days after ICU admission, defined by a modified Rankin2024-01-01T00:00:00Z2024 Dec2025-04-04T21:46:04.626Z2025-04-04T21:46:04.626ZS-EPMC116595363969971410.1186/s13613-024-01405-z