{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Zhang M"],"pubmed_abstract":["<h4>Background</h4><i>Helicobacter pylori</i> (<i>H. pylori</i>) may be present in the intestinal mucosa of patients with inflammatory bowel disease (IBD), which is a chronic inflammation of the gastrointestinal tract. The role of <i>H. pylori</i> in the pathogenesis of IBD remains unclear. In this study, bioinformatics techniques were used to investigate the correlation and co-pathogenic pathways between <i>H. pylori</i> and IBD.<h4>Methods</h4>The following matrix data were downloaded from the GEO database: <i>H. pylori</i>-associated gastritis, GSE233973 and GSE27411; and IBD, GSE3365 and GSE179285. Differential gene analysis was performed via the limma software package in the R environment. A protein-protein interaction (PPI) network of DEGs was constructed via the STRING database. Cyt"],"journal":["Frontiers in immunology"],"pagination":["1492810"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11659760"],"repository":["biostudies-literature"],"pubmed_title":["Common diagnostic biomarkers and molecular mechanisms of <i>Helicobacter pylori</i> infection and inflammatory bowel disease."],"pmcid":["PMC11659760"],"pubmed_authors":["Chen Q","Xie Y","Zhang Y","Luo L","Wang F","Zhang M","Liu T"],"additional_accession":[]},"is_claimable":false,"name":"Common diagnostic biomarkers and molecular mechanisms of <i>Helicobacter pylori</i> infection and inflammatory bowel disease.","description":"<h4>Background</h4><i>Helicobacter pylori</i> (<i>H. pylori</i>) may be present in the intestinal mucosa of patients with inflammatory bowel disease (IBD), which is a chronic inflammation of the gastrointestinal tract. The role of <i>H. pylori</i> in the pathogenesis of IBD remains unclear. In this study, bioinformatics techniques were used to investigate the correlation and co-pathogenic pathways between <i>H. pylori</i> and IBD.<h4>Methods</h4>The following matrix data were downloaded from the GEO database: <i>H. pylori</i>-associated gastritis, GSE233973 and GSE27411; and IBD, GSE3365 and GSE179285. Differential gene analysis was performed via the limma software package in the R environment. A protein-protein interaction (PPI) network of DEGs was constructed via the STRING database. Cyt","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-04-08T19:26:53.824Z","creation":"2025-04-04T21:11:24.621Z"},"accession":"S-EPMC11659760","cross_references":{"pubmed":["39712025"],"doi":["10.3389/fimmu.2024.1492810"]}}