biostudies-literatureUnknown15Zhang M<h4>Background</h4><i>Helicobacter pylori</i> (<i>H. pylori</i>) may be present in the intestinal mucosa of patients with inflammatory bowel disease (IBD), which is a chronic inflammation of the gastrointestinal tract. The role of <i>H. pylori</i> in the pathogenesis of IBD remains unclear. In this study, bioinformatics techniques were used to investigate the correlation and co-pathogenic pathways between <i>H. pylori</i> and IBD.<h4>Methods</h4>The following matrix data were downloaded from the GEO database: <i>H. pylori</i>-associated gastritis, GSE233973 and GSE27411; and IBD, GSE3365 and GSE179285. Differential gene analysis was performed via the limma software package in the R environment. A protein-protein interaction (PPI) network of DEGs was constructed via the STRING database. CytFrontiers in immunology1492810https://www.ebi.ac.uk/biostudies/studies/S-EPMC11659760biostudies-literatureCommon diagnostic biomarkers and molecular mechanisms of <i>Helicobacter pylori</i> infection and inflammatory bowel disease.PMC11659760Chen QXie YZhang YLuo LWang FZhang MLiu TfalseCommon diagnostic biomarkers and molecular mechanisms of <i>Helicobacter pylori</i> infection and inflammatory bowel disease.<h4>Background</h4><i>Helicobacter pylori</i> (<i>H. pylori</i>) may be present in the intestinal mucosa of patients with inflammatory bowel disease (IBD), which is a chronic inflammation of the gastrointestinal tract. The role of <i>H. pylori</i> in the pathogenesis of IBD remains unclear. In this study, bioinformatics techniques were used to investigate the correlation and co-pathogenic pathways between <i>H. pylori</i> and IBD.<h4>Methods</h4>The following matrix data were downloaded from the GEO database: <i>H. pylori</i>-associated gastritis, GSE233973 and GSE27411; and IBD, GSE3365 and GSE179285. Differential gene analysis was performed via the limma software package in the R environment. A protein-protein interaction (PPI) network of DEGs was constructed via the STRING database. Cyt2024-01-01T00:00:00Z20242026-04-08T19:26:53.824Z2025-04-04T21:11:24.621ZS-EPMC116597603971202510.3389/fimmu.2024.1492810