biostudies-literatureLi Lthe National Natural Science Foundation Program of ChinaHunan Provincial Natural Science Foundation Youth Fund ProjectHunan Outstanding Youth Fund Project220https://www.ebi.ac.uk/biostudies/studies/S-EPMC11660932biostudies-literatureUnknown43(1)<h4>Background</h4>Although many studies shown that the risk of congenital heart disease (CHD) was closely related to genetic and environmental factors, the exact mechanism was still unclear. This study was to assess the association of maternal folic acid supplementation (FAS), the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene polymorphisms in offspring and their interaction effects with the risk of CHD and its subtypes.<h4>Methods</h4>A case-control study was conducted on 595 children with CHD and 605 healthy child controls. The multivariate logistic regression model was used to assess the association of maternal FAS, offspring MTRR gene polymorphisms and their interaction effects with CHD and its subtypes.<h4>Results</h4>This study shown that maternal FAS Journal of health, population, and nutritionAssociation of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.PMC11660932820736532023JJ410222022JJ10087Chen QOu JLuo MZhang YQin JWang TChen YLi LfalseAssociation of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.<h4>Background</h4>Although many studies shown that the risk of congenital heart disease (CHD) was closely related to genetic and environmental factors, the exact mechanism was still unclear. This study was to assess the association of maternal folic acid supplementation (FAS), the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene polymorphisms in offspring and their interaction effects with the risk of CHD and its subtypes.<h4>Methods</h4>A case-control study was conducted on 595 children with CHD and 605 healthy child controls. The multivariate logistic regression model was used to assess the association of maternal FAS, offspring MTRR gene polymorphisms and their interaction effects with CHD and its subtypes.<h4>Results</h4>This study shown that maternal FAS 2024-01-01T00:00:00Z2024 Dec2026-06-01T19:49:18.559Z2025-04-04T00:39:02.457ZS-EPMC116609323970254210.1186/s41043-024-00699-w