{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang L"],"funding":["Guangdong High-Level University Development Program","Natural Science Foundation of Hubei Province","Guangdong Science and Technology Innovation Foundation","National Natural Science Foundation of China","Shantou University","Xiangyang Science and Technology Program"],"pagination":["4533-4543"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11661682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(24)"],"pubmed_abstract":["Unconjugated bilirubin (UCB) visualization is valuable for early bilirubin encephalopathy (BE) diagnosis and management. UCB neurotoxicity is a challenge, necessitating improved imaging modalities for precise localization and characterization. This study developed a noninvasive method for UCB imaging in the brain using chemical exchange saturation transfer (CEST) magnetic resonance imaging, which visualizes UCB distribution through amide-bulk water proton exchange, a process termed bilirubin CEST (Bil-CEST) imaging. Bil-CEST imaging parameters were initially optimized; the exchange rate of the amide protons of UCB was calculated. Bil-CEST imaging characteristics and specificity were assessed using in vitro images of UCB solutions under different conditions and images of other brain metabol"],"journal":["ACS chemical neuroscience"],"pubmed_title":["Visualization of Unconjugated Bilirubin In Vivo with a Novel Approach Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging in a Rat Model."],"pmcid":["PMC11661682"],"funding_grant_id":["STKJ2021148","002-18120302","2022YL15A","82020108016","2022CFB960"],"pubmed_authors":["Cai R","Guan J","Yang L","Cao Z","Zhang X","Jia Y","Wu R","Lin Y","Cheng Y","Zhuang Z"],"additional_accession":[]},"is_claimable":false,"name":"Visualization of Unconjugated Bilirubin In Vivo with a Novel Approach Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging in a Rat Model.","description":"Unconjugated bilirubin (UCB) visualization is valuable for early bilirubin encephalopathy (BE) diagnosis and management. UCB neurotoxicity is a challenge, necessitating improved imaging modalities for precise localization and characterization. This study developed a noninvasive method for UCB imaging in the brain using chemical exchange saturation transfer (CEST) magnetic resonance imaging, which visualizes UCB distribution through amide-bulk water proton exchange, a process termed bilirubin CEST (Bil-CEST) imaging. Bil-CEST imaging parameters were initially optimized; the exchange rate of the amide protons of UCB was calculated. Bil-CEST imaging characteristics and specificity were assessed using in vitro images of UCB solutions under different conditions and images of other brain metabol","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-06T14:41:46.884Z","creation":"2026-05-31T03:10:23.082Z"},"accession":"S-EPMC11661682","cross_references":{"pubmed":["39614805"],"doi":["10.1021/acschemneuro.4c00604"]}}