{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stockley JH"],"funding":["AOU NIH HHS","Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","European Research Council","NIDDK NIH HHS","NIHR Cambridge Biomedical Research Centre","Medical Research Council","National Institute for Health Research (NIHR)","All of Us Research Program","Wellcome Trust"],"pagination":["399-421"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11662986"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["73(2)"],"pubmed_abstract":["Oligodendrocytes (OLs) of the central nervous system require iron for proteolipid biosynthesis during the myelination process. Although most heme is found complexed to hemoglobin in red blood cells, surprisingly, we found that Slc48a1, encoding the heme transporter Hrg1, is expressed at higher levels in OLs than any other cell type in rodent and humans. We confirmed in situ that Hrg1 is expressed in OLs but not their precursors (OPCs) and found that Hrg1 proteins in CNS white matter co-localized within myelin sheaths. In older Hrg1 null mutant mice we observed reduced expression of myelin associated glycoprotein (Mag) and ultrastructural myelin defects reminiscent of Mag-null animals, suggesting myelin adhesion deficiency. Further, we confirmed reduced myelin iron levels in Hrg1 null anima"],"journal":["Glia"],"pubmed_title":["Oligodendrocyte Slc48a1 (Hrg1) encodes a functional heme transporter required for myelin integrity."],"pmcid":["PMC11662986"],"funding_grant_id":["R01DK125740","108139/Z/15/Z","NIHR203312","MC_PC_17230","R01 DK125740","789054"],"pubmed_authors":["Rock AS","Lam G","Pek RH","Zhao C","Jordan GD","Gunter S","O'Connor R","Vaquie AM","Stockley JH","Bartels T","Holmqvist S","Yamamoto D","Dillon S","Hill M","Franklin RJM","Hamza I","Rowitch DH","Xu Z","Chambers IG","Bodine DM"],"additional_accession":[]},"is_claimable":false,"name":"Oligodendrocyte Slc48a1 (Hrg1) encodes a functional heme transporter required for myelin integrity.","description":"Oligodendrocytes (OLs) of the central nervous system require iron for proteolipid biosynthesis during the myelination process. Although most heme is found complexed to hemoglobin in red blood cells, surprisingly, we found that Slc48a1, encoding the heme transporter Hrg1, is expressed at higher levels in OLs than any other cell type in rodent and humans. We confirmed in situ that Hrg1 is expressed in OLs but not their precursors (OPCs) and found that Hrg1 proteins in CNS white matter co-localized within myelin sheaths. In older Hrg1 null mutant mice we observed reduced expression of myelin associated glycoprotein (Mag) and ultrastructural myelin defects reminiscent of Mag-null animals, suggesting myelin adhesion deficiency. Further, we confirmed reduced myelin iron levels in Hrg1 null anima","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-01T05:14:53.741Z","creation":"2025-04-07T13:36:03.439Z"},"accession":"S-EPMC11662986","cross_references":{"pubmed":["39501820"],"doi":["10.1002/glia.24641"]}}