biostudies-literatureHasso-Agopsowicz MWorld Health OrganizationUniversidade Federal de GoiásBill and Melinda Gates Foundation105424https://www.ebi.ac.uk/biostudies/studies/S-EPMC11663754biostudies-literatureUnknown110<h4>Background</h4>To date, global priorities for new vaccine R&D have not been systematically identified for endemic pathogens. As part of Immunisation Agenda 2030 (IA2030), we have systematically identified priority endemic pathogens for new vaccine R&D based on country and regional stakeholder values to address this need.<h4>Methods</h4>MCDA surveys targeting policy makers and immunisation stakeholders in each World Health Organization (WHO) region were used to weight eight criteria for prioritisation. Applying those weights to regional pathogen data yielded regional top ten pathogen lists, which are intended to inform regional deliberations on R&D priorities. The regional top ten lists were combined into an IA2030 global priority list. To inform R&D, use cases for new vaccines and monoEBioMedicineIdentifying WHO global priority endemic pathogens for vaccine research and development (R&amp;D) using multi-criteria decision analysis (MCDA): an objective of the Immunization Agenda 2030.PMC11663754001INV-005318Sparrow ERao RHollm-Delgado MGGiersing BKarron RAHwang AHasso-Agopsowicz MUmbelino-Walker IAsante KPSheel MfalseIdentifying WHO global priority endemic pathogens for vaccine research and development (R&amp;D) using multi-criteria decision analysis (MCDA): an objective of the Immunization Agenda 2030.<h4>Background</h4>To date, global priorities for new vaccine R&D have not been systematically identified for endemic pathogens. As part of Immunisation Agenda 2030 (IA2030), we have systematically identified priority endemic pathogens for new vaccine R&D based on country and regional stakeholder values to address this need.<h4>Methods</h4>MCDA surveys targeting policy makers and immunisation stakeholders in each World Health Organization (WHO) region were used to weight eight criteria for prioritisation. Applying those weights to regional pathogen data yielded regional top ten pathogen lists, which are intended to inform regional deliberations on R&D priorities. The regional top ten lists were combined into an IA2030 global priority list. To inform R&D, use cases for new vaccines and mono2024-01-01T00:00:00Z2024 Dec2025-04-04T20:28:29.985Z2025-04-04T20:28:29.985ZS-EPMC116637543950070510.1016/j.ebiom.2024.105424