biostudies-literatureAn AYNIAID NIH HHS105411https://www.ebi.ac.uk/biostudies/studies/S-EPMC11663757biostudies-literatureUnknown110<h4>Background</h4>Neonatal sepsis is a deadly disease with non-specific clinical signs, delaying diagnosis and treatment. There remains a need for early biomarkers to facilitate timely intervention. Our objective was to identify neonatal sepsis gene expression biomarkers that could predict sepsis at birth, prior to clinical presentation.<h4>Methods</h4>Among 720 initially healthy full-term neonates in two hospitals (The Gambia, West Africa), we identified 21 newborns who were later hospitalized for sepsis in the first 28 days of life, split into early-onset sepsis (EOS, onset ≤7 days of life) and late-onset sepsis (LOS, onset 8-28 days of life), 12 neonates later hospitalized for localized infection without evidence of systemic involvement, and 33 matched control neonates who remained heaEBioMedicinePredictive gene expression signature diagnoses neonatal sepsis before clinical presentation.PMC11663757K08 AI168487Amenyogbe NMatlam JPRao SMartino DHuang JParker EPKLarsen KFord RBurnell KGolding CNDibbasey TNdure Jvan den Biggelaar AHJWariri ONjie-Jobe JFatou BBennike TBVo DOdumade OABen-Othman RChen VMasiria GDhillon BKKirarock WPalma PDiray-Arce JHe DOzonoff AChen JCooney MIdoko OTDibassey TFrancis FSanchez-Schmitz GDarboe APlotkin AAn AYSanca LSyphurs Cvan Haren SDImam ASmolen KKCheckervarty AKraft KPak JLee AHBjerregaard-Andersen MPettengill MAMontante SMcEnaney KLevy OBlimkie TMKaroly MERichmond PCAngelidou AAKollmann TRSteen HStrandmark JLiu MPomat WSBlimkie THoch AActon EMBrook BCai BHinshaw SHMarchant ALasky-Su JVignolo SSchaltz-Buchholzer FKampmann BFalsafi RSaleu GTebbutt SJEPIC ConsortiumShannon CPBennike THarbeson DJBao WSingh AMalek MRoberts ESmith MHancock REWVarankovich NMcLoughlin CLiu AMartino DJNguyen AMorrocchi EBrinkman RRCox MfalsePredictive gene expression signature diagnoses neonatal sepsis before clinical presentation.<h4>Background</h4>Neonatal sepsis is a deadly disease with non-specific clinical signs, delaying diagnosis and treatment. There remains a need for early biomarkers to facilitate timely intervention. Our objective was to identify neonatal sepsis gene expression biomarkers that could predict sepsis at birth, prior to clinical presentation.<h4>Methods</h4>Among 720 initially healthy full-term neonates in two hospitals (The Gambia, West Africa), we identified 21 newborns who were later hospitalized for sepsis in the first 28 days of life, split into early-onset sepsis (EOS, onset ≤7 days of life) and late-onset sepsis (LOS, onset 8-28 days of life), 12 neonates later hospitalized for localized infection without evidence of systemic involvement, and 33 matched control neonates who remained hea2024-01-01T00:00:00Z2024 Dec2026-04-08T19:49:03.178Z2025-04-03T23:14:04.174ZS-EPMC116637573947223610.1016/j.ebiom.2024.105411