biostudies-literatureUnknown39(1)Traidl SLilly Deutschland GmbHPfizer Inc.PfizerLEO Pharma GmbHLilly DeutschlandGalderma S.A.SanofiAbbVie Deutschland GmbH & Co<h4>Background</h4>There are conflicting data on a potential association between obesity and atopic dermatitis (AD). The purpose of this study was to investigate the relationship between obesity and AD disease severity.<h4>Methods</h4>Patients from the TREATgermany registry cohort were divided into three groups according to their body mass index (BMI). Due to low numbers, underweight patients (BMI <18.5 kg/m²) were excluded from the analysis. Physician- and patient-reported disease severity scores as well as additional phenotypic characteristics were evaluated for association with BMI. Generalized linear mixed models and multinomial logit models, respectively, were applied to investigate the association of BMI, age, sex and current systemic AD treatment with disease severity.<h4Journal of the European Academy of Dermatology and Venereology : JEADV136-144https://www.ebi.ac.uk/biostudies/studies/S-EPMC11664465biostudies-literatureObesity is linked to disease severity in moderate to severe atopic dermatitis-Data from the prospective observational TREATgermany registry.PMC11664465Quist STREATgermany Study GroupSchwarz BSchenck FWerfel TAbraham SEffendy ISchakel KHandrick CAsmussen AWollenberg ASiegels DKroeger NGorriahn-Maiterth HKind BSchafer TFischer SSticherling MTraidl SHeinrich LRamaker-Brunke JHeratizadeh ABong AHarder IWeidinger SSchmitt JHollstein MMErtner KAugustin MPinter AfalseObesity is linked to disease severity in moderate to severe atopic dermatitis-Data from the prospective observational TREATgermany registry.<h4>Background</h4>There are conflicting data on a potential association between obesity and atopic dermatitis (AD). The purpose of this study was to investigate the relationship between obesity and AD disease severity.<h4>Methods</h4>Patients from the TREATgermany registry cohort were divided into three groups according to their body mass index (BMI). Due to low numbers, underweight patients (BMI <18.5 kg/m²) were excluded from the analysis. Physician- and patient-reported disease severity scores as well as additional phenotypic characteristics were evaluated for association with BMI. Generalized linear mixed models and multinomial logit models, respectively, were applied to investigate the association of BMI, age, sex and current systemic AD treatment with disease severity.<h42025-01-01T00:00:00Z2025 Jan2025-04-03T23:14:02.871Z2025-04-03T23:14:02.871ZS-EPMC116644653866151110.1111/jdv.20042