{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Barba L"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["e16581"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11664725"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(1)"],"pubmed_abstract":["<h4>Background</h4>We aimed to investigate the prognostic role of β-synuclein in comparison to that of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS).<h4>Methods</h4>We measured serum concentrations of β-synuclein, NfL and GFAP 24 h after hospital admission in 213 consecutive patients with moderate-to-severe AIS. We investigated the association between serum biomarkers and radiological/clinical characteristics, 3-months mortality and functional outcome on the modified Rankin Scale (mRS).<h4>Results</h4>In 213 patients with AIS [mean age: 76.1 (±12.5) years, 53.1% males, median NIHSS score on admission: 13 (IQR: 9-17)], higher levels of β-synuclein, NfL and GFAP were associated with higher NIHSS "],"journal":["European journal of neurology"],"pubmed_title":["Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation."],"pmcid":["PMC11664725"],"funding_grant_id":["SFB1279","374031971 - TRR 240","413657723"],"pubmed_authors":["Hametner C","D'Anna L","Abu-Rumeileh S","Halbgebauer S","Kollikowski AM","Heuschmann PU","Haeusler KG","Vollmuth C","Romoli M","Otto M","Barba L","Schuhmann MK","Stoll G","Ungethum K","Oeckl P","Essig F","Steinacker P","Pham M","Neugebauer H"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation.","description":"<h4>Background</h4>We aimed to investigate the prognostic role of β-synuclein in comparison to that of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS).<h4>Methods</h4>We measured serum concentrations of β-synuclein, NfL and GFAP 24 h after hospital admission in 213 consecutive patients with moderate-to-severe AIS. We investigated the association between serum biomarkers and radiological/clinical characteristics, 3-months mortality and functional outcome on the modified Rankin Scale (mRS).<h4>Results</h4>In 213 patients with AIS [mean age: 76.1 (±12.5) years, 53.1% males, median NIHSS score on admission: 13 (IQR: 9-17)], higher levels of β-synuclein, NfL and GFAP were associated with higher NIHSS ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-03T23:13:54.089Z","creation":"2025-04-03T23:13:54.089Z"},"accession":"S-EPMC11664725","cross_references":{"pubmed":["39714176"],"doi":["10.1111/ene.16581"]}}