biostudies-literatureBarba LDeutsche Forschungsgemeinschafte16581https://www.ebi.ac.uk/biostudies/studies/S-EPMC11664725biostudies-literatureUnknown32(1)<h4>Background</h4>We aimed to investigate the prognostic role of β-synuclein in comparison to that of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS).<h4>Methods</h4>We measured serum concentrations of β-synuclein, NfL and GFAP 24 h after hospital admission in 213 consecutive patients with moderate-to-severe AIS. We investigated the association between serum biomarkers and radiological/clinical characteristics, 3-months mortality and functional outcome on the modified Rankin Scale (mRS).<h4>Results</h4>In 213 patients with AIS [mean age: 76.1 (±12.5) years, 53.1% males, median NIHSS score on admission: 13 (IQR: 9-17)], higher levels of β-synuclein, NfL and GFAP were associated with higher NIHSS European journal of neurologyPrognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation.PMC11664725SFB1279374031971 - TRR 240413657723Hametner CD'Anna LAbu-Rumeileh SHalbgebauer SKollikowski AMHeuschmann PUHaeusler KGVollmuth CRomoli MOtto MBarba LSchuhmann MKStoll GUngethum KOeckl PEssig FSteinacker PPham MNeugebauer HfalsePrognostic serum biomarkers of synaptic, neuronal and glial injury in patients with acute ischemic stroke of the anterior circulation.<h4>Background</h4>We aimed to investigate the prognostic role of β-synuclein in comparison to that of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) for predicting functional outcome after acute ischemic stroke (AIS).<h4>Methods</h4>We measured serum concentrations of β-synuclein, NfL and GFAP 24 h after hospital admission in 213 consecutive patients with moderate-to-severe AIS. We investigated the association between serum biomarkers and radiological/clinical characteristics, 3-months mortality and functional outcome on the modified Rankin Scale (mRS).<h4>Results</h4>In 213 patients with AIS [mean age: 76.1 (±12.5) years, 53.1% males, median NIHSS score on admission: 13 (IQR: 9-17)], higher levels of β-synuclein, NfL and GFAP were associated with higher NIHSS 2025-01-01T00:00:00Z2025 Jan2025-04-03T23:13:54.089Z2025-04-03T23:13:54.089ZS-EPMC116647253971417610.1111/ene.16581