{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(12)"],"submitter":["Copaescu AM"],"pubmed_abstract":["<h4>Background</h4>In an exploratory study to assess the potential to individualize T-cell diagnostics in antibiotic-associated severe T-cell mediated hypersensitivity, we focused on drug reaction with eosinophilia and systemic symptoms (DRESS) and the related cytokine outputs IL-4 and IL-5.<h4>Methods</h4>Patients with well-phenotyped RegiSCAR ≥4 DRESS, positive intradermal skin testing, and a previous negative IFN-γ Enzyme-Linked ImmunoSpot (ELISpot) assay were prospectively recruited. We specifically performed an ELISpot assay with IL-4 and IL-5 cytokine outputs. As comparative controls, these cytokine outputs were performed simultaneously in patients with a positive <i>ex vivo</i> IFN-γ release ELISpot result.<h4>Results</h4>Four antibiotic-associated DRESS cases were included. The IL-"],"journal":["The World Allergy Organization journal"],"pagination":["101002"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11665396"],"repository":["biostudies-literature"],"pubmed_title":["Exploring cytokine outputs for &lt;i&gt;ex vivo&lt;/i&gt; diagnostics in drug reaction with eosinophilia and systemic symptoms (DRESS)."],"pmcid":["PMC11665396"],"pubmed_authors":["Phillips EJ","for Australasian Registry of Severe Cutaneous Adverse Reactions (AUS-SCAR)","James F","Mouhtouris E","Trubiano JA","Goh MSY","Copaescu AM"],"additional_accession":[]},"is_claimable":false,"name":"Exploring cytokine outputs for &lt;i&gt;ex vivo&lt;/i&gt; diagnostics in drug reaction with eosinophilia and systemic symptoms (DRESS).","description":"<h4>Background</h4>In an exploratory study to assess the potential to individualize T-cell diagnostics in antibiotic-associated severe T-cell mediated hypersensitivity, we focused on drug reaction with eosinophilia and systemic symptoms (DRESS) and the related cytokine outputs IL-4 and IL-5.<h4>Methods</h4>Patients with well-phenotyped RegiSCAR ≥4 DRESS, positive intradermal skin testing, and a previous negative IFN-γ Enzyme-Linked ImmunoSpot (ELISpot) assay were prospectively recruited. We specifically performed an ELISpot assay with IL-4 and IL-5 cytokine outputs. As comparative controls, these cytokine outputs were performed simultaneously in patients with a positive <i>ex vivo</i> IFN-γ release ELISpot result.<h4>Results</h4>Four antibiotic-associated DRESS cases were included. The IL-","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-18T12:43:20.409Z","creation":"2025-04-06T22:09:54.89Z"},"accession":"S-EPMC11665396","cross_references":{"pubmed":["39717677"],"doi":["10.1016/j.waojou.2024.101002"]}}