{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Science and Technology Commission of Shanghai Municipality","National Natural Science Foundation of China"],"pagination":["107982"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11665689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["300(12)"],"pubmed_abstract":["Effective cancer immunotherapy relies on enhancing the host's immune response, particularly by boosting T cell-mediated cytotoxicity against tumor cells. In this study, we identify CWF19-like cell cycle control factor 1 (CWF19L1) as a novel splicing regulator that enhances T cell-mediated cytotoxicity. CWF19L1 interacts prominently with key splicing factors within the nucleus, including components of the U5 small nuclear ribonucleoprotein and the pre-mRNA processing factor 19 (PRPF19) complex. Deficiency of CWF19L1 disrupts alternative splicing of immune-related genes, resulting in diminished expression of cytotoxic molecules. Furthermore, CWF19L1 plays a critical role in promoting T cell-mediated antitumor responses by upregulating the expression of effector cytokines. Our findings unveil"],"journal":["The Journal of biological chemistry"],"pubmed_title":["CWF19L1 promotes T-cell cytotoxicity through the regulation of alternative splicing."],"pmcid":["PMC11665689"],"funding_grant_id":["21JC1400900","32370926","20ZR1407600","82071780"],"pubmed_authors":["Yi J","Yang H","Zhang D","Zhang Y","Zhang H","Wei G","Ren T","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"CWF19L1 promotes T-cell cytotoxicity through the regulation of alternative splicing.","description":"Effective cancer immunotherapy relies on enhancing the host's immune response, particularly by boosting T cell-mediated cytotoxicity against tumor cells. In this study, we identify CWF19-like cell cycle control factor 1 (CWF19L1) as a novel splicing regulator that enhances T cell-mediated cytotoxicity. CWF19L1 interacts prominently with key splicing factors within the nucleus, including components of the U5 small nuclear ribonucleoprotein and the pre-mRNA processing factor 19 (PRPF19) complex. Deficiency of CWF19L1 disrupts alternative splicing of immune-related genes, resulting in diminished expression of cytotoxic molecules. Furthermore, CWF19L1 plays a critical role in promoting T cell-mediated antitumor responses by upregulating the expression of effector cytokines. Our findings unveil","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-04-08T19:47:18.343Z","creation":"2025-04-06T22:12:45.306Z"},"accession":"S-EPMC11665689","cross_references":{"pubmed":["39542248"],"doi":["10.1016/j.jbc.2024.107982"]}}