{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Roy SK"],"funding":["European Research Council"],"pagination":["1373-1379"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11665774"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(6)"],"pubmed_abstract":["We introduce two water-soluble excited state intramolecular proton transfer (ESIPT) based fluorescent turn-on probes responding to inorganic polyphosphates. These ESIPT probes enable specific detection of short-chain inorganic polyphosphates over a range of different condensed phosphates. The probes are weakly emissive in their off-state due to the blocking of ESIPT by Cu<sup>2+</sup> coordination. Removal of the copper ion through decomplexation by the analyte accesses the on-state. The probes detect polyphosphates over other biologically occurring phosphates, pyrophosphate, and nucleotides such as ATP, ADP, GTP. An optimal fluorescence response is observed with the short-chain polyphosphate polyP<sub>8</sub>. Furthermore, the probe shows selectivity towards linear polyphosphates over cyc"],"journal":["Organic & biomolecular chemistry"],"pubmed_title":["ESIPT fluorescence turn-on sensors for detection of short chain inorganic polyphosphate in water."],"pmcid":["PMC11665774"],"funding_grant_id":["864246"],"pubmed_authors":["Hinkelmann R","Jessen HJ","Moser S","Durr-Mayer T","Roy SK"],"additional_accession":[]},"is_claimable":false,"name":"ESIPT fluorescence turn-on sensors for detection of short chain inorganic polyphosphate in water.","description":"We introduce two water-soluble excited state intramolecular proton transfer (ESIPT) based fluorescent turn-on probes responding to inorganic polyphosphates. These ESIPT probes enable specific detection of short-chain inorganic polyphosphates over a range of different condensed phosphates. The probes are weakly emissive in their off-state due to the blocking of ESIPT by Cu<sup>2+</sup> coordination. Removal of the copper ion through decomplexation by the analyte accesses the on-state. The probes detect polyphosphates over other biologically occurring phosphates, pyrophosphate, and nucleotides such as ATP, ADP, GTP. An optimal fluorescence response is observed with the short-chain polyphosphate polyP<sub>8</sub>. Furthermore, the probe shows selectivity towards linear polyphosphates over cyc","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-06T13:59:27.959Z","creation":"2025-04-06T13:59:27.959Z"},"accession":"S-EPMC11665774","cross_references":{"pubmed":["39714782"],"doi":["10.1039/d4ob01926a"]}}