biostudies-literatureYamada HYU.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)American Cancer Society (American Cancer Society, Inc.)NCI NIH HHSNIGMS NIH HHS288https://www.ebi.ac.uk/biostudies/studies/S-EPMC11666716biostudies-literatureUnknown8(1)The high incidence and mortality rates of colorectal cancer (CRC) in Alabama African Americans (AAs) and Oklahoma American Indians (AIs) are recognized as cancer disparities, yet the underlying causes have been poorly demonstrated. By evaluating CRC whole-exome sequencing and mutational profiles, here we report sets of mutated genes whose frequencies differed significantly (p < 0.05) in a race-specific manner. Secondary screening with cancer database identified "survival-critical genes (SCGs)" (i.e., genes whose mutations/alterations are associated with significant differences in the patients' survival rates) among the differentially mutated genes. Notable SCGs with race-pronounced variants were different from DEGs and their involved pathways included nucleotide catabolism and cell cycle cNPJ precision oncologyMutational disparities in colorectal cancers of White Americans, Alabama African Americans, And Oklahoma American Indians.PMC116667169 R01 CA 213987-05S1MRSG 15-136-01-CCEU54 CA118948P20 GM103447P30 CA225520R01 CA213987P20GM1036395U54CA118948P20 GM103639Manne URao CVO'Neill PHRout MXu CSanghera DKAfaq FMorris KTYamada HYfalseMutational disparities in colorectal cancers of White Americans, Alabama African Americans, And Oklahoma American Indians.The high incidence and mortality rates of colorectal cancer (CRC) in Alabama African Americans (AAs) and Oklahoma American Indians (AIs) are recognized as cancer disparities, yet the underlying causes have been poorly demonstrated. By evaluating CRC whole-exome sequencing and mutational profiles, here we report sets of mutated genes whose frequencies differed significantly (p < 0.05) in a race-specific manner. Secondary screening with cancer database identified "survival-critical genes (SCGs)" (i.e., genes whose mutations/alterations are associated with significant differences in the patients' survival rates) among the differentially mutated genes. Notable SCGs with race-pronounced variants were different from DEGs and their involved pathways included nucleotide catabolism and cell cycle c2024-01-01T00:00:00Z2024 Dec2026-06-01T23:07:23.773Z2025-04-07T13:36:48.279ZS-EPMC116667163971588510.1038/s41698-024-00782-9