biostudies-literaturePark TNIA NIH HHSFoundation for the National Institutes of HealthKorean government grantsMinistry of Science and ICT, South Korea8787-8801https://www.ebi.ac.uk/biostudies/studies/S-EPMC11667488biostudies-literatureUnknown20(12)<h4>Introduction</h4>Despite the recognized importance of including ethnic diversity in Alzheimer's disease (AD) research, substantial knowledge gaps remain, particularly in Asian populations.<h4>Methods</h4>RNA sequencing was performed on blood samples from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) to perform differential gene expression (DGE), gene co-expression network, gene-set enrichment, and machine learning analyses for amyloid beta (Aβ) deposition on positron emission tomography.<h4>Results</h4>DGE analysis identified 265 dysregulated genes associated with Aβ deposition and replicated three AD-associated genes in an independent Korean cohort. Network analysis identified two modules related to pathways including a natural killAlzheimer's & dementia : the journal of the Alzheimer's AssociationGenome-wide transcriptome analysis of Aβ deposition on PET in a Korean cohort.PMC11667488HI18C0630P30 AG010133U19 AG024904R01 AG057739NRF-2014M3C7A1046042RS-2023-KH136195U01AG068057R01 AG019771U19 AG074879R01AG068193RS-2022-00165636R01LM012535HI19C0149U01 AG072177P30 AG072976T32AG0714442020R1C1C1013718R01LM013463U01AG072177U19AG074879Han SWLiu SGao HByun MSLiu YPark YHKim YKCho MChaudhuri SRisacher SLBice PJHuang YNKim MJRosewood TSaykin AJJung GLee DYAhn HLee JYPark THwang JKim SCraft HNho KYi DfalseGenome-wide transcriptome analysis of Aβ deposition on PET in a Korean cohort.<h4>Introduction</h4>Despite the recognized importance of including ethnic diversity in Alzheimer's disease (AD) research, substantial knowledge gaps remain, particularly in Asian populations.<h4>Methods</h4>RNA sequencing was performed on blood samples from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) to perform differential gene expression (DGE), gene co-expression network, gene-set enrichment, and machine learning analyses for amyloid beta (Aβ) deposition on positron emission tomography.<h4>Results</h4>DGE analysis identified 265 dysregulated genes associated with Aβ deposition and replicated three AD-associated genes in an independent Korean cohort. Network analysis identified two modules related to pathways including a natural kill2024-01-01T00:00:00Z2024 Dec2025-04-03T23:14:10.088Z2025-04-03T23:14:10.088ZS-EPMC116674883951396310.1002/alz.14348