{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Augustin B"],"funding":["NHLBI NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["431"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11667828"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(1)"],"pubmed_abstract":["<h4>Background</h4>Lipids play a critical role in defense against sepsis. We sought to investigate gene expression and lipidomic patterns of lipid dysregulation in sepsis.<h4>Methods</h4>Data from four adult sepsis studies were analyzed and findings were investigated in two external datasets. Previously characterized lipid dysregulation subphenotypes of hypolipoprotein (HYPO; low lipoproteins, increased mortality) and normolipoprotein (NORMO; higher lipoproteins, lower mortality) were studied. Leukocytes collected within 24 h of sepsis underwent RNA sequencing (RNAseq) and shotgun plasma lipidomics was performed.<h4>Results</h4>Of 288 included patients, 43% were HYPO and 57% were NORMO. HYPO patients exhibited higher median SOFA scores (9 vs 5, p = < 0.001), vasopressor use (67% vs 34%, p "],"journal":["Critical care (London, England)"],"pubmed_title":["Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality."],"pmcid":["PMC11667828"],"funding_grant_id":["R01 GM133815","R35HL150784","R01HL162124","R01CA265907","K23 GM144802","K08GM151392","K12HL133304","K08 GM151392","R35 HL150784","R01GM133815","R01 HL162124","R01 CA265907","K12 HL133304","K23GM144802"],"pubmed_authors":["Sulaiman D","Cagmat E","Hopson C","Labilloy G","Augustin B","Reddy ST","Wu D","Smith L","Graim K","Jacob V","Bertrand A","Hofmaenner DA","Datta S","Guirgis FW","Black LP","Shavit JA"],"additional_accession":[]},"is_claimable":false,"name":"Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality.","description":"<h4>Background</h4>Lipids play a critical role in defense against sepsis. We sought to investigate gene expression and lipidomic patterns of lipid dysregulation in sepsis.<h4>Methods</h4>Data from four adult sepsis studies were analyzed and findings were investigated in two external datasets. Previously characterized lipid dysregulation subphenotypes of hypolipoprotein (HYPO; low lipoproteins, increased mortality) and normolipoprotein (NORMO; higher lipoproteins, lower mortality) were studied. Leukocytes collected within 24 h of sepsis underwent RNA sequencing (RNAseq) and shotgun plasma lipidomics was performed.<h4>Results</h4>Of 288 included patients, 43% were HYPO and 57% were NORMO. HYPO patients exhibited higher median SOFA scores (9 vs 5, p = < 0.001), vasopressor use (67% vs 34%, p ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-01T23:06:11.974Z","creation":"2025-04-06T17:36:08.327Z"},"accession":"S-EPMC11667828","cross_references":{"pubmed":["39716214"],"doi":["10.1186/s13054-024-05216-3"]}}