biostudies-literatureAugustin BNHLBI NIH HHSNCI NIH HHSNIGMS NIH HHS431https://www.ebi.ac.uk/biostudies/studies/S-EPMC11667828biostudies-literatureUnknown28(1)<h4>Background</h4>Lipids play a critical role in defense against sepsis. We sought to investigate gene expression and lipidomic patterns of lipid dysregulation in sepsis.<h4>Methods</h4>Data from four adult sepsis studies were analyzed and findings were investigated in two external datasets. Previously characterized lipid dysregulation subphenotypes of hypolipoprotein (HYPO; low lipoproteins, increased mortality) and normolipoprotein (NORMO; higher lipoproteins, lower mortality) were studied. Leukocytes collected within 24 h of sepsis underwent RNA sequencing (RNAseq) and shotgun plasma lipidomics was performed.<h4>Results</h4>Of 288 included patients, 43% were HYPO and 57% were NORMO. HYPO patients exhibited higher median SOFA scores (9 vs 5, p = < 0.001), vasopressor use (67% vs 34%, p Critical care (London, England)Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality.PMC11667828R01 GM133815R35HL150784R01HL162124R01CA265907K23 GM144802K08GM151392K12HL133304K08 GM151392R35 HL150784R01GM133815R01 HL162124R01 CA265907K12 HL133304K23GM144802Sulaiman DCagmat EHopson CLabilloy GAugustin BReddy STWu DSmith LGraim KJacob VBertrand AHofmaenner DADatta SGuirgis FWBlack LPShavit JAfalseMultiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality.<h4>Background</h4>Lipids play a critical role in defense against sepsis. We sought to investigate gene expression and lipidomic patterns of lipid dysregulation in sepsis.<h4>Methods</h4>Data from four adult sepsis studies were analyzed and findings were investigated in two external datasets. Previously characterized lipid dysregulation subphenotypes of hypolipoprotein (HYPO; low lipoproteins, increased mortality) and normolipoprotein (NORMO; higher lipoproteins, lower mortality) were studied. Leukocytes collected within 24 h of sepsis underwent RNA sequencing (RNAseq) and shotgun plasma lipidomics was performed.<h4>Results</h4>Of 288 included patients, 43% were HYPO and 57% were NORMO. HYPO patients exhibited higher median SOFA scores (9 vs 5, p = < 0.001), vasopressor use (67% vs 34%, p 2024-01-01T00:00:00Z2024 Dec2026-06-01T23:06:11.974Z2025-04-06T17:36:08.327ZS-EPMC116678283971621410.1186/s13054-024-05216-3