{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["481(24)"],"submitter":["Oldham KEA"],"pubmed_abstract":["Regulation of protein longevity via the ubiquitin (Ub) - proteasome pathway is fundamental to eukaryotic biology. Ubiquitin E3 ligases (E3s) interact with substrate proteins and provide specificity to the pathway. A small subset of E3s bind to specific exposed N-termini (N-degrons) and promote the ubiquitination of the bound protein. Collectively these E3s, and other N-degron binding proteins, are known as N-recognins. There is considerable functional divergence between fungi, animal, and plant N-recognins. In plants, at least three proteins (PRT1, PRT6, and BIG) participate in the Arg/N-degron pathway. PRT1 has demonstrated E3 ligase activity, whereas PRT6 and BIG are candidate E3s. The Arg/N-degron pathway plays a central role in plant development, germination, and submersion tolerance. "],"journal":["The Biochemical journal"],"pagination":["1949-1965"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11668491"],"repository":["biostudies-literature"],"pubmed_title":["Ubiquitin E3 ligases in the plant Arg/N-degron pathway."],"pmcid":["PMC11668491"],"pubmed_authors":["Mabbitt PD","Oldham KEA"],"additional_accession":[]},"is_claimable":false,"name":"Ubiquitin E3 ligases in the plant Arg/N-degron pathway.","description":"Regulation of protein longevity via the ubiquitin (Ub) - proteasome pathway is fundamental to eukaryotic biology. Ubiquitin E3 ligases (E3s) interact with substrate proteins and provide specificity to the pathway. A small subset of E3s bind to specific exposed N-termini (N-degrons) and promote the ubiquitination of the bound protein. Collectively these E3s, and other N-degron binding proteins, are known as N-recognins. There is considerable functional divergence between fungi, animal, and plant N-recognins. In plants, at least three proteins (PRT1, PRT6, and BIG) participate in the Arg/N-degron pathway. PRT1 has demonstrated E3 ligase activity, whereas PRT6 and BIG are candidate E3s. The Arg/N-degron pathway plays a central role in plant development, germination, and submersion tolerance. ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-03T04:55:25.363Z","creation":"2025-04-06T17:33:50.287Z"},"accession":"S-EPMC11668491","cross_references":{"pubmed":["39670824"],"doi":["10.1042/BCJ20240132"]}}