biostudies-literatureLou YFundamental Research Funds for the Central Universitiesthe Research Grants Council of the Hong Kong Special Administrative RegionNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Key Research and Development Program of ChinaNatural Science Foundation of Jiangsu Provincee2408816https://www.ebi.ac.uk/biostudies/studies/S-EPMC11672269biostudies-literatureUnknown11(48)Constructing nanostructures, such as nanopores, within metallic glasses (MGs) holds great promise for further unlocking their electrochemical capabilities. However, the MGs typically exhibit intrinsic atomic-scale isotropy, posing a significant challenge in directly fabricating anisotropic nanostructures using conventional chemical synthesis. Herein a selective leaching approach, which focuses on tailoring the uniformity of atomic ordering, is introduced to achieve pore-engineered Pd-Ni-P MG. This innovative approach significantly boosts the number of exposed active sites, thereby enhancing the electrochemical sensitivity for glucose detection. Electrochemical tests reveal that the nanoporous Pd-Ni-P MG exhibits high sensitivity (3.19 mA mm⁻¹ cm⁻²) and remarkable stability (97.7Advanced science (Weinheim, Baden-Wurttemberg, Germany)Tailoring Atomic Ordering Uniformity Enables Selectively Leached Nanoporous Pd-Ni-P Metallic Glass for Enhanced Glucose Sensing.PMC116722695222210430922010307BK2020001951871120222750892021YFB3802800N_CityU173/2212261160364Tan LLiu HLi JYu RLou YZhu HYing HLiu SWang XLLan SWu ZYao ZZeng JfalseTailoring Atomic Ordering Uniformity Enables Selectively Leached Nanoporous Pd-Ni-P Metallic Glass for Enhanced Glucose Sensing.Constructing nanostructures, such as nanopores, within metallic glasses (MGs) holds great promise for further unlocking their electrochemical capabilities. However, the MGs typically exhibit intrinsic atomic-scale isotropy, posing a significant challenge in directly fabricating anisotropic nanostructures using conventional chemical synthesis. Herein a selective leaching approach, which focuses on tailoring the uniformity of atomic ordering, is introduced to achieve pore-engineered Pd-Ni-P MG. This innovative approach significantly boosts the number of exposed active sites, thereby enhancing the electrochemical sensitivity for glucose detection. Electrochemical tests reveal that the nanoporous Pd-Ni-P MG exhibits high sensitivity (3.19 mA mm⁻¹ cm⁻²) and remarkable stability (97.72024-01-01T00:00:00Z2024 Dec2025-04-21T14:00:25.897Z2025-04-21T14:00:25.897ZS-EPMC116722693949853610.1002/advs.202408816