{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song JQ"],"funding":["Guangdong Provincial Department of Science and Technology","Double First-Class Project of China Pharmaceutical University","2024 Guangdong Pharmaceutical University's \"Discipline Training Excellence, Innovation and Quality Improvement\" Engineering Team Project","Department of Science and Technology of Guangdong Province","Natural Medicines of China Pharmaceutical University","Top Talent Support Program for Young and Middle-aged People of Wuxi Health Committee","National Natural Science Foundation of China","Open Project of Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education of Hainan Medical University"],"pagination":["e2410550"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11672292"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(48)"],"pubmed_abstract":["Macrophage-mediated inflammatory responses including pyroptosis are involved in the pathogenesis of sepsis and acute lung injury (ALI), for which there are currently no effective therapeutic treatments. The natural product (+)-Balasubramide is an eight-membered lactam compound extracted from the leaves of the Sri Lanka plant Clausena Indica and has shown anti-inflammatory activities, but its poor pharmacokinetic properties limit its further application for ALI. In this study, a compound (+)3C-20 is discovered with improved both pharmacokinetic properties and anti-inflammatory activity from a series of (+)-Balasubramide derivatives. The compound (+)3C-20 exhibits a markedly enhanced inhibitory effect against LPS-induced expressions of pro-inflammatory factors in mouse macrophages and human "],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Discovery of Balasubramide Derivative with Tissue-Specific Anti-Inflammatory Activity Against Acute Lung Injury by Targeting VDAC1."],"pmcid":["PMC11672292"],"funding_grant_id":["2015A020211031","No.2024ZZ05","Grant No. TMIT2024Z03","CPUQNJC22_02","2016A020217022","No. BJ2023066","82205110","81973512","82174010","SKLNMKF202405"],"pubmed_authors":["Cai B","Lin HS","Pang T","Shi L","Liu K","Liu QB","Song JQ","Shen LJ","Wang HJ","Ye LB"],"additional_accession":[]},"is_claimable":false,"name":"Discovery of Balasubramide Derivative with Tissue-Specific Anti-Inflammatory Activity Against Acute Lung Injury by Targeting VDAC1.","description":"Macrophage-mediated inflammatory responses including pyroptosis are involved in the pathogenesis of sepsis and acute lung injury (ALI), for which there are currently no effective therapeutic treatments. The natural product (+)-Balasubramide is an eight-membered lactam compound extracted from the leaves of the Sri Lanka plant Clausena Indica and has shown anti-inflammatory activities, but its poor pharmacokinetic properties limit its further application for ALI. In this study, a compound (+)3C-20 is discovered with improved both pharmacokinetic properties and anti-inflammatory activity from a series of (+)-Balasubramide derivatives. The compound (+)3C-20 exhibits a markedly enhanced inhibitory effect against LPS-induced expressions of pro-inflammatory factors in mouse macrophages and human ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-01T20:04:26.296Z","creation":"2025-04-19T21:26:34.019Z"},"accession":"S-EPMC11672292","cross_references":{"pubmed":["39556713"],"doi":["10.1002/advs.202410550"]}}