biostudies-literatureLei JNational Natural Science Foundation of China1151https://www.ebi.ac.uk/biostudies/studies/S-EPMC11673371biostudies-literatureUnknown22(1)<h4>Background</h4>Mitochondrial transcription elongation factor (TEFM) is a recently discovered factor involved in mitochondrial DNA replication and transcription. Previous studies have reported that abnormal TEFM expression can disrupt the assembly of mitochondrial respiratory chain and thus mitochondrial function. However, the role of TEFM on Uterine corpus endometrial carcinoma (UCEC) progression remains unclear. The present study aims to investigate the expression of TEFM in tumor tissue of UCEC and the effect of abnormal TEFM expression on malignant phenotype of UCEC cells.<h4>Methods</h4>The expressions of TEFM were measured in tumor tissues and cell lines of UCEC by immunohistochemistry, Western blotting, and real-time quantitative PCR assays. Besides, the effects of TEFM knockdownJournal of translational medicineTEFM facilitates uterine corpus endometrial carcinoma progression by activating ROS-NFκB pathway.PMC116733718237307082273229Qi LCui MLei JChen JSi LJin YGuo RWang LJiang ZLiu YGuo JLai TYang QBao DZhu QFan CfalseTEFM facilitates uterine corpus endometrial carcinoma progression by activating ROS-NFκB pathway.<h4>Background</h4>Mitochondrial transcription elongation factor (TEFM) is a recently discovered factor involved in mitochondrial DNA replication and transcription. Previous studies have reported that abnormal TEFM expression can disrupt the assembly of mitochondrial respiratory chain and thus mitochondrial function. However, the role of TEFM on Uterine corpus endometrial carcinoma (UCEC) progression remains unclear. The present study aims to investigate the expression of TEFM in tumor tissue of UCEC and the effect of abnormal TEFM expression on malignant phenotype of UCEC cells.<h4>Methods</h4>The expressions of TEFM were measured in tumor tissues and cell lines of UCEC by immunohistochemistry, Western blotting, and real-time quantitative PCR assays. Besides, the effects of TEFM knockdown2024-01-01T00:00:00Z2024 Dec2025-04-27T01:31:42.294Z2025-04-06T18:19:56.885ZS-EPMC116733713973105310.1186/s12967-024-05833-0