{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang S"],"funding":["Fourth National Survey of Traditional Chinese Medicine Resources","Experimental Technology Research Project of Southwest University","National Key Research and Development Program of China"],"pagination":["13729"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11676366"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(24)"],"pubmed_abstract":["<i>Atropa belladonna</i> is a medicinal plant and an important source for the commercial production of tropane alkaloids (TAs), such as scopolamine and hyoscyamine, which are used clinically for their anticholinergic properties. In this study, we identified 16 metallocarboxypeptidase inhibitor (MCPI) genes from <i>A. belladonna</i> (<i>AbMCPIs</i>), which are grouped into three subgroups based on phylogenetic relationships and are distributed across 10 chromosomes. Promoter analysis showed that most <i>cis-regulatory</i> elements were related to defense and stress responses, such as drought, low-temperature, ABA (abscisic acid), GA (gibberellin), auxin, light and MeJA responsiveness. A gene encoding a putative metallocarboxypeptidase inhibitor (<i>AbMCPI8</i>) is cloned from <i>A. belladon"],"journal":["International journal of molecular sciences"],"pubmed_title":["Genome-Wide Analysis of the Metallocarboxypeptidase Inhibitor Family Reveals That <i>AbMCPI8</i> Affects Root Development and Tropane Alkaloid Production in <i>Atropa belladonna</i>."],"pmcid":["PMC11676366"],"funding_grant_id":["2022YFD1201600","20191217-540124 and 20200501-542329","SYJ2024028"],"pubmed_authors":["Wan S","Liao Z","Chen M","Zeng L","Liao S","Wang Y","Zhang C","Yang S","Lan X"],"additional_accession":[]},"is_claimable":false,"name":"Genome-Wide Analysis of the Metallocarboxypeptidase Inhibitor Family Reveals That <i>AbMCPI8</i> Affects Root Development and Tropane Alkaloid Production in <i>Atropa belladonna</i>.","description":"<i>Atropa belladonna</i> is a medicinal plant and an important source for the commercial production of tropane alkaloids (TAs), such as scopolamine and hyoscyamine, which are used clinically for their anticholinergic properties. In this study, we identified 16 metallocarboxypeptidase inhibitor (MCPI) genes from <i>A. belladonna</i> (<i>AbMCPIs</i>), which are grouped into three subgroups based on phylogenetic relationships and are distributed across 10 chromosomes. Promoter analysis showed that most <i>cis-regulatory</i> elements were related to defense and stress responses, such as drought, low-temperature, ABA (abscisic acid), GA (gibberellin), auxin, light and MeJA responsiveness. A gene encoding a putative metallocarboxypeptidase inhibitor (<i>AbMCPI8</i>) is cloned from <i>A. belladon","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-05-22T03:17:38.122Z","creation":"2025-04-05T09:28:32.675Z"},"accession":"S-EPMC11676366","cross_references":{"pubmed":["39769489"],"doi":["10.3390/ijms252413729"]}}