biostudies-literatureZhang XProject of the Science and Technology Program of Shaanxi Academy of ScienceXi'an Innovation Capacity Foundation Strengthening Plan-Agricultural Technology Research and Development ProjectNatural Science Basic Research Program of Shaanxi1599https://www.ebi.ac.uk/biostudies/studies/S-EPMC11676476biostudies-literatureUnknown14(12)<i>Gynostemma pentaphyllum</i> is a traditional Chinese medicinal plant of considerable application value and commercial potential, primarily due to its production of various bioactive compounds, particularly dammarane-type triterpenoid saponins that are structurally analogous to ginsenosides. Oxidosqualene cyclase (OSC), a pivotal enzyme in the biosynthesis of triterpenoid metabolites in plants, catalyzes the conversion of oxidosqualene into triterpenoid precursors, which are essential components of the secondary metabolites found in <i>G. pentaphyllum</i>. To elucidate the role of <i>OSC</i> gene family members in the synthesis of gypenosides within <i>G. pentaphyllum</i>, this study undertook a comprehensive genome-wide identification and characterization of <i>OSC</i> genes within <i>GLife (Basel, Switzerland)Genome-Wide Identification and Characterization of <i>OSC</i> Gene Family in <i>Gynostemma pentaphyllum</i> (Cucurbitaceae).PMC116764762023-JC-QN-02202021JH-05-00622024k-32Yang HZhang XWang XChen CfalseGenome-Wide Identification and Characterization of <i>OSC</i> Gene Family in <i>Gynostemma pentaphyllum</i> (Cucurbitaceae).<i>Gynostemma pentaphyllum</i> is a traditional Chinese medicinal plant of considerable application value and commercial potential, primarily due to its production of various bioactive compounds, particularly dammarane-type triterpenoid saponins that are structurally analogous to ginsenosides. Oxidosqualene cyclase (OSC), a pivotal enzyme in the biosynthesis of triterpenoid metabolites in plants, catalyzes the conversion of oxidosqualene into triterpenoid precursors, which are essential components of the secondary metabolites found in <i>G. pentaphyllum</i>. To elucidate the role of <i>OSC</i> gene family members in the synthesis of gypenosides within <i>G. pentaphyllum</i>, this study undertook a comprehensive genome-wide identification and characterization of <i>OSC</i> genes within <i>G2024-01-01T00:00:00Z2024 Dec2026-05-23T03:20:17.509Z2026-05-23T03:08:19.366ZS-EPMC116764763976830810.3390/life14121599