{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mitsueda R"],"funding":["Reiko Mitsueda","Naohiko Seki","Hiroko Toda"],"pagination":["60"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11677261"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(6)"],"pubmed_abstract":["Our recently created RNA-sequence-based microRNA (miRNA) expression signature in breast cancer clinical specimens revealed that some <i>miR-30</i> family members were significantly downregulated in cancer tissues. Based on TCGA database analyses, we observed that among the <i>miR-30</i> family members, <i>miR-30a-3p</i> (the passenger strand derived from pre-<i>miR-30a</i>) was significantly downregulated in breast cancer (BC) clinical specimens, and its low expression predicted worse prognoses. Ectopic expression assays showed that <i>miR-30a-3p</i> transfected cancer cells (MDA-MB-157 and MDA-MB-231) had their aggressive phenotypes significantly suppressed, e.g., their proliferation, migration, and invasion abilities. These data indicated that <i>miR-30a-3p</i> acted as a tumor-suppressi"],"journal":["Non-coding RNA"],"pubmed_title":["Identification of Tumor-Suppressive <i>miR-30a-3p</i> Controlled Genes: <i>ANLN</i> as a Therapeutic Target in Breast Cancer."],"pmcid":["PMC11677261"],"funding_grant_id":["24K11746","22K08705","24K12641"],"pubmed_authors":["Toda H","Shinden Y","Nagata A","Yasudome R","Kato M","Mitsueda R","Nakajo A","Seki N","Tomioka Y"],"additional_accession":[]},"is_claimable":false,"name":"Identification of Tumor-Suppressive <i>miR-30a-3p</i> Controlled Genes: <i>ANLN</i> as a Therapeutic Target in Breast Cancer.","description":"Our recently created RNA-sequence-based microRNA (miRNA) expression signature in breast cancer clinical specimens revealed that some <i>miR-30</i> family members were significantly downregulated in cancer tissues. Based on TCGA database analyses, we observed that among the <i>miR-30</i> family members, <i>miR-30a-3p</i> (the passenger strand derived from pre-<i>miR-30a</i>) was significantly downregulated in breast cancer (BC) clinical specimens, and its low expression predicted worse prognoses. Ectopic expression assays showed that <i>miR-30a-3p</i> transfected cancer cells (MDA-MB-157 and MDA-MB-231) had their aggressive phenotypes significantly suppressed, e.g., their proliferation, migration, and invasion abilities. These data indicated that <i>miR-30a-3p</i> acted as a tumor-suppressi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-04-19T03:27:46.726Z","creation":"2025-04-19T21:26:55.634Z"},"accession":"S-EPMC11677261","cross_references":{"pubmed":["39728605"],"doi":["10.3390/ncrna10060060"]}}