biostudies-literatureHan CNational Natural Science Foundation of ChinaShanghai Science and Technology Development Funds5892https://www.ebi.ac.uk/biostudies/studies/S-EPMC11679863biostudies-literatureUnknown29(24)<i>Salvia miltiorrhiza</i>, the valuable traditional Chinese medicinal plant, has been used in clinics for thousands of years. The water-soluble salvianolic acid compounds are bioactive substances used in treating many diseases. Gibberellins (GAs) are growth-promoting phytohormones that regulate plant growth and development. Previous studies have demonstrated that GAs can promote salvianolic acid accumulation in <i>S. miltiorrhiza</i>; however, the underlying mechanism requires further investigation. Here, we identified a GA-induced R2R3MYB transcription factor (TF), <i>Sm</i>MYB71, from a transcriptome library of GA-treated <i>S. miltiorrhiza</i>. <i>Sm</i>MYB71 was highly expressed in the root of <i>S. miltiorrhiza</i> and localized to the nucleus. <i>Sm</i>MYB71-knockout hairy roots shoMolecules (Basel, Switzerland)Gibberellin-Induced Transcription Factor <i>Sm</i>MYB71 Negatively Regulates Salvianolic Acid Biosynthesis in <i>Salvia miltiorrhiza</i>.PMC1167986322YF145960082204560Yu LDong XFeng XChen MXing XFeng YZhou ZSang WHuang THe YHao HLi BHan CWang YWu WfalseGibberellin-Induced Transcription Factor <i>Sm</i>MYB71 Negatively Regulates Salvianolic Acid Biosynthesis in <i>Salvia miltiorrhiza</i>.<i>Salvia miltiorrhiza</i>, the valuable traditional Chinese medicinal plant, has been used in clinics for thousands of years. The water-soluble salvianolic acid compounds are bioactive substances used in treating many diseases. Gibberellins (GAs) are growth-promoting phytohormones that regulate plant growth and development. Previous studies have demonstrated that GAs can promote salvianolic acid accumulation in <i>S. miltiorrhiza</i>; however, the underlying mechanism requires further investigation. Here, we identified a GA-induced R2R3MYB transcription factor (TF), <i>Sm</i>MYB71, from a transcriptome library of GA-treated <i>S. miltiorrhiza</i>. <i>Sm</i>MYB71 was highly expressed in the root of <i>S. miltiorrhiza</i> and localized to the nucleus. <i>Sm</i>MYB71-knockout hairy roots sho2024-01-01T00:00:00Z2024 Dec2026-04-13T03:21:46.738Z2026-04-13T03:12:21.695ZS-EPMC116798633976998210.3390/molecules29245892