{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(6)"],"submitter":["Rizwan A"],"pubmed_abstract":["<h4>Background/objective</h4>Medullary thyroid carcinoma (MTC) is an uncommon thyroid cancer (TC), rarely found in hyperfunctioning goiter.<h4>Case report</h4>We present a case of a woman treated for breast carcinoma (BCA) found to have a benign hyperfunctioning nodular goiter, its likely transformation to MTC, and its treatment. Family history revealed papillary thyroid cancer in her nephew.<h4>Discussion</h4>Most TCs in hyperfunctioning nodules are differentiated carcinomas. Familial MTC or MTC in association with multiple endocrine neoplasia 2 is the expected genetic association in this case.<h4>Conclusion</h4>The association of BCA and MTC may have been coincidental, given the high prevalence of BCA in females. It could have been the result of a common genetic precursor of both tumors "],"journal":["AACE clinical case reports"],"pagination":["249-252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11680752"],"repository":["biostudies-literature"],"pubmed_title":["Medullary Thyroid Carcinoma in the Background of Non-neoplastic Toxic Nodular Goiter."],"pmcid":["PMC11680752"],"pubmed_authors":["Ameen A","Akhter S","Saad M","Rizwan A","Fatima S"],"additional_accession":[]},"is_claimable":false,"name":"Medullary Thyroid Carcinoma in the Background of Non-neoplastic Toxic Nodular Goiter.","description":"<h4>Background/objective</h4>Medullary thyroid carcinoma (MTC) is an uncommon thyroid cancer (TC), rarely found in hyperfunctioning goiter.<h4>Case report</h4>We present a case of a woman treated for breast carcinoma (BCA) found to have a benign hyperfunctioning nodular goiter, its likely transformation to MTC, and its treatment. Family history revealed papillary thyroid cancer in her nephew.<h4>Discussion</h4>Most TCs in hyperfunctioning nodules are differentiated carcinomas. Familial MTC or MTC in association with multiple endocrine neoplasia 2 is the expected genetic association in this case.<h4>Conclusion</h4>The association of BCA and MTC may have been coincidental, given the high prevalence of BCA in females. It could have been the result of a common genetic precursor of both tumors ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov-Dec","modification":"2025-04-04T02:36:41.816Z","creation":"2025-04-04T02:36:41.816Z"},"accession":"S-EPMC11680752","cross_references":{"pubmed":["39734499"],"doi":["10.1016/j.aace.2024.08.008"]}}