{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Kros JM"],"pubmed_abstract":["In previous work we discovered that T lymphocytes play a prominent role in the rise of brain metastases of ER-negative breast cancers. In the present study we explored how T lymphocytes promote breast cancer cell penetration through the blood brain barrier (BBB). An in vitro BBB model was employed to study the effects of T lymphocytes on BBB trespassing capacity of three different breast carcinoma cell lines. Differential protein expression was explored by comparing the proteomes of the breast cancer cells before and after co-culture with activated T lymphocytes using liquid chromatography-mass spectrometry (LC-MS). siRNA was used to silence protein expression in the breast cancer cells to study contribution to in vitro BBB passage. Furthermore, protein expression in primary breast cancer "],"journal":["Scientific reports"],"pagination":["31516"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11682172"],"repository":["biostudies-literature"],"pubmed_title":["T cell induced expression of Coronin-1A facilitates blood-brain barrier transmigration of breast cancer cells."],"pmcid":["PMC11682172"],"pubmed_authors":["Mustafa DAM","Kros JM","Dik WA","Belcaid Z","Luider TM","Zeneyedpour L","Pedrosa RMSM"],"additional_accession":[]},"is_claimable":false,"name":"T cell induced expression of Coronin-1A facilitates blood-brain barrier transmigration of breast cancer cells.","description":"In previous work we discovered that T lymphocytes play a prominent role in the rise of brain metastases of ER-negative breast cancers. In the present study we explored how T lymphocytes promote breast cancer cell penetration through the blood brain barrier (BBB). An in vitro BBB model was employed to study the effects of T lymphocytes on BBB trespassing capacity of three different breast carcinoma cell lines. Differential protein expression was explored by comparing the proteomes of the breast cancer cells before and after co-culture with activated T lymphocytes using liquid chromatography-mass spectrometry (LC-MS). siRNA was used to silence protein expression in the breast cancer cells to study contribution to in vitro BBB passage. Furthermore, protein expression in primary breast cancer ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-05-26T14:02:54.489Z","creation":"2025-04-04T21:48:49.365Z"},"accession":"S-EPMC11682172","cross_references":{"pubmed":["39733107"],"doi":["10.1038/s41598-024-83301-x"]}}