biostudies-literatureUnknown54(12)Lee J<h4>Background and objectives</h4>Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a life-threatening inherited arrhythmogenic disorder. Recently, <i>RYR2</i>, the major CPVT-causative gene, was associated with neuropsychiatric manifestations. We aimed to analyze the clinical presentations, neuropsychiatric manifestations, and treatment outcomes of children with CPVT.<h4>Methods</h4>We retrospectively reviewed 23 patients diagnosed with CPVT before 19 years of age. Genetic analysis, history of neuropsychiatric manifestations, changes in ventricular arrhythmia burden before and after treatment, occurrence of cardiac events, and overall survival (OS) were investigated.<h4>Results</h4><i>RYR2</i> variants were identified in 17 patients, and 14 were classified as pathogenic or lKorean circulation journal853-864https://www.ebi.ac.uk/biostudies/studies/S-EPMC11685342biostudies-literatureTreatment Outcomes in Children With Catecholaminergic Polymorphic Ventricular Tachycardia: A Single Institutional Experience.PMC11685342Kwon BSLee SYSong MKLee JKim GBBae EJKo JMfalseTreatment Outcomes in Children With Catecholaminergic Polymorphic Ventricular Tachycardia: A Single Institutional Experience.<h4>Background and objectives</h4>Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a life-threatening inherited arrhythmogenic disorder. Recently, <i>RYR2</i>, the major CPVT-causative gene, was associated with neuropsychiatric manifestations. We aimed to analyze the clinical presentations, neuropsychiatric manifestations, and treatment outcomes of children with CPVT.<h4>Methods</h4>We retrospectively reviewed 23 patients diagnosed with CPVT before 19 years of age. Genetic analysis, history of neuropsychiatric manifestations, changes in ventricular arrhythmia burden before and after treatment, occurrence of cardiac events, and overall survival (OS) were investigated.<h4>Results</h4><i>RYR2</i> variants were identified in 17 patients, and 14 were classified as pathogenic or l2024-01-01T00:00:00Z2024 Dec2025-04-04T21:49:03.212Z2025-04-04T21:49:03.212ZS-EPMC116853423973377810.4070/kcj.2024.0183