{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li C"],"funding":["Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund (HMRF)","Innovation and Technology Commission (ITF)","Research Grants Council, University Grants Committee","Research Grants Council, University Grants Committee (RGC, UGC)","Innovation and Technology Commission","Food and Health Bureau of the Government of the Hong Kong Special Administrative Region | Health and Medical Research Fund"],"pagination":["10772"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11686133"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop an organoid-based system to reproducibly propagate HRV-C, and characterize virus-host interaction using respiratory organoids. We demonstrate that airway organoids sustain serial virus passage with the aid of CYT387-mediated immunosuppression, whereas nasal organoids that more closely simulate the upper airway achieve this without any intervention. Nasal organoids are more susceptible to HRV-C than airway organoids. Intriguingly, upon HRV-C infection, we observe an innate immune response that is stronger in airway organoids than in nasal organoids, which is re"],"journal":["Nature communications"],"pubmed_title":["Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction."],"pmcid":["PMC11686133"],"funding_grant_id":["C7042-21G","17113724","17105420","COVID1903010-project 11","CID-HKU1-3","Health@InnoHK"],"pubmed_authors":["Cai JP","Li C","Huang J","Chan JF","Wan Z","Yue M","Wong KK","Clevers H","Huang L","Zhang S","Zhou Y","Liu X","Xue W","Chiu MC","Lan Q","Chu H","Zhu X","Yip CC","Yuen KY","Yu Y","Deng Y","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction.","description":"The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop an organoid-based system to reproducibly propagate HRV-C, and characterize virus-host interaction using respiratory organoids. We demonstrate that airway organoids sustain serial virus passage with the aid of CYT387-mediated immunosuppression, whereas nasal organoids that more closely simulate the upper airway achieve this without any intervention. Nasal organoids are more susceptible to HRV-C than airway organoids. Intriguingly, upon HRV-C infection, we observe an innate immune response that is stronger in airway organoids than in nasal organoids, which is re","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-01T23:19:04.585Z","creation":"2025-04-05T17:00:42.568Z"},"accession":"S-EPMC11686133","cross_references":{"pubmed":["39738014"],"doi":["10.1038/s41467-024-55076-2"]}}