{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jeon BC"],"funding":["National Research Foundation of Korea (NRF)","Korea Research Institute of Bioscience and Biotechnology (KRIBB)","National Research Council of Science and Technology (National Research Council of Science & Technology)"],"pagination":["68-82"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11686140"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["V(D)J recombination secures the production of functional immunoglobulin (Ig) genes and antibody diversity during the early stages of B-cell development through long-distance interactions mediated by cis-regulatory elements and trans-acting factors. O-GlcNAcylation is a dynamic and reversible posttranslational modification of nuclear and cytoplasmic proteins that regulates various protein functions, including DNA-binding affinity and protein-protein interactions. However, the effects of O-GlcNAcylation on proteins involved in V(D)J recombination remain largely unknown. To elucidate this relationship, we downregulated O-GlcNAcylation in a mouse model by administering an O-GlcNAc inhibitor or restricting the consumption of a regular diet. Interestingly, the inhibition of O-GlcNAcylation in mi"],"journal":["Cellular & molecular immunology"],"pubmed_title":["Dynamic O-GlcNAcylation governs long-range chromatin interactions in V(D)J recombination during early B-cell development."],"pmcid":["PMC11686140"],"funding_grant_id":["KGM9942421","NTC2642311","2021R1I1A2057945","2021R1A2C1012477","2022M3E5F1016693","ZYM9382312","2020R1I1A3073845"],"pubmed_authors":["Park AK","Jeon BC","Park Y","Kim TD","Kim YJ","Na KM","Lee J","Hwang H","Lim J","Song MR","An D","Park SK"],"additional_accession":[]},"is_claimable":false,"name":"Dynamic O-GlcNAcylation governs long-range chromatin interactions in V(D)J recombination during early B-cell development.","description":"V(D)J recombination secures the production of functional immunoglobulin (Ig) genes and antibody diversity during the early stages of B-cell development through long-distance interactions mediated by cis-regulatory elements and trans-acting factors. O-GlcNAcylation is a dynamic and reversible posttranslational modification of nuclear and cytoplasmic proteins that regulates various protein functions, including DNA-binding affinity and protein-protein interactions. However, the effects of O-GlcNAcylation on proteins involved in V(D)J recombination remain largely unknown. To elucidate this relationship, we downregulated O-GlcNAcylation in a mouse model by administering an O-GlcNAc inhibitor or restricting the consumption of a regular diet. Interestingly, the inhibition of O-GlcNAcylation in mi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-06T19:57:32.708Z","creation":"2026-06-04T03:12:32.755Z"},"accession":"S-EPMC11686140","cross_references":{"pubmed":["39627609"],"doi":["10.1038/s41423-024-01236-9"]}}