biostudies-literatureLuk CBritish Heart FoundationMedical Research CouncilDiabetes UKWellcome TrustBiotechnology and Biological Sciences Research Council170https://www.ebi.ac.uk/biostudies/studies/S-EPMC11696296biostudies-literatureUnknown16(1)During recent decades, changes in lifestyle have led to widespread nutritional obesity and its related complications. Remodelling adipose tissue as a therapeutic goal for obesity and its complications has attracted much attention and continues to be actively explored. The endothelium lines all blood vessels and is close to all cells, including adipocytes. The endothelium has been suggested to act as a paracrine organ. We explore the role of endothelial insulin-like growth factor-1 receptor (IGF-1R), as a paracrine modulator of white adipose phenotype. We show that a reduction in endothelial IGF-1R expression in the presence of high-fat feeding in male mice leads to depot-specific beneficial white adipose tissue remodelling, increases whole-body energy expenditure and enhances insulin sensiNature communicationsParacrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice.PMC11696296FS/19/59/34896BB/R013500/1PG/14/54/30939110158/Z/15/ZMR/X009734/1RG/15/7/31521PG/18/82/3412016/0005382220257/Z/20/ZFS/12/80/29821FS/19/59/34896AVidal-Puig ABruns AFKearney MTGriffin KJSukumar PMacCannell ADVHartley RCSimon Futers TWarmke NPrag HAOzber CHLimumpornpetch SWheatcroft SBSimmons KJYuldasheva NYBrown OIMurphy MPWitte KKMughal RDrozd MSkromna AWilkinson CGLuk CWatt NTBeech DJBridge KIMoran AViswambharan HScragg JLSmith JStraw SHaywood NJCubbon RMCheng CWMakava NWalker AMRoberts LDfalseParacrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice.During recent decades, changes in lifestyle have led to widespread nutritional obesity and its related complications. Remodelling adipose tissue as a therapeutic goal for obesity and its complications has attracted much attention and continues to be actively explored. The endothelium lines all blood vessels and is close to all cells, including adipocytes. The endothelium has been suggested to act as a paracrine organ. We explore the role of endothelial insulin-like growth factor-1 receptor (IGF-1R), as a paracrine modulator of white adipose phenotype. We show that a reduction in endothelial IGF-1R expression in the presence of high-fat feeding in male mice leads to depot-specific beneficial white adipose tissue remodelling, increases whole-body energy expenditure and enhances insulin sensi2025-01-01T00:00:00Z2025 Jan2026-06-02T02:05:07.734Z2025-04-05T22:52:55.091ZS-EPMC116962963974781510.1038/s41467-024-54669-1