{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Ma Q"],"pubmed_abstract":["Compared to the sluggish kinetics observed in methanol-mediated side-chain alkylation of methyl groups with sp<sup>3</sup> C-H bonds, CO<sub>2</sub> hydrogenation emerges as a sustainable alternative strategy, yet it remains a challenge. Here, as far as we know, it is first reported that using CO<sub>2</sub> hydrogenation replacing methanol can conduct the side-chain alkylation of 4-methylpyridine (MEPY) over a binary metal oxide-zeolite Zn<sub>40</sub>Zr<sub>60</sub>O/CsX tandem catalyst (ZZO/CsX). This ZZO/CsX catalyst can achieve 19.6% MEPY single-pass conversion and 82% 4-ethylpyridine (ETPY) selectivity by using CO<sub>2</sub> hydrogenation, which is 6.5 times more active than methanol as an alkylation agent. The excellent catalytic performance is realized on the basis of the dual fun"],"journal":["Nature communications"],"pagination":["140"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11697012"],"repository":["biostudies-literature"],"pubmed_title":["C-C bond coupling with sp&lt;sup&gt;3&lt;/sup&gt; C-H bond via active intermediates from CO&lt;sub&gt;2&lt;/sub&gt; hydrogenation."],"pmcid":["PMC11697012"],"pubmed_authors":["Yang H","Li G","Ma Q","Fan W","Bitter JH","Li C","Zhang R","Li Z","Xie J","Zeng J","Cheng J","Wu X","Mao Z"],"additional_accession":[]},"is_claimable":false,"name":"C-C bond coupling with sp&lt;sup&gt;3&lt;/sup&gt; C-H bond via active intermediates from CO&lt;sub&gt;2&lt;/sub&gt; hydrogenation.","description":"Compared to the sluggish kinetics observed in methanol-mediated side-chain alkylation of methyl groups with sp<sup>3</sup> C-H bonds, CO<sub>2</sub> hydrogenation emerges as a sustainable alternative strategy, yet it remains a challenge. Here, as far as we know, it is first reported that using CO<sub>2</sub> hydrogenation replacing methanol can conduct the side-chain alkylation of 4-methylpyridine (MEPY) over a binary metal oxide-zeolite Zn<sub>40</sub>Zr<sub>60</sub>O/CsX tandem catalyst (ZZO/CsX). This ZZO/CsX catalyst can achieve 19.6% MEPY single-pass conversion and 82% 4-ethylpyridine (ETPY) selectivity by using CO<sub>2</sub> hydrogenation, which is 6.5 times more active than methanol as an alkylation agent. The excellent catalytic performance is realized on the basis of the dual fun","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-22T09:00:40.851Z","creation":"2025-04-05T22:53:19.512Z"},"accession":"S-EPMC11697012","cross_references":{"pubmed":["39747077"],"doi":["10.1038/s41467-024-55640-w"]}}