biostudies-literatureUnknown16(1)Ma QCompared to the sluggish kinetics observed in methanol-mediated side-chain alkylation of methyl groups with sp³ C-H bonds, CO₂ hydrogenation emerges as a sustainable alternative strategy, yet it remains a challenge. Here, as far as we know, it is first reported that using CO₂ hydrogenation replacing methanol can conduct the side-chain alkylation of 4-methylpyridine (MEPY) over a binary metal oxide-zeolite Zn₄₀Zr₆₀O/CsX tandem catalyst (ZZO/CsX). This ZZO/CsX catalyst can achieve 19.6% MEPY single-pass conversion and 82% 4-ethylpyridine (ETPY) selectivity by using CO₂ hydrogenation, which is 6.5 times more active than methanol as an alkylation agent. The excellent catalytic performance is realized on the basis of the dual funNature communications140https://www.ebi.ac.uk/biostudies/studies/S-EPMC11697012biostudies-literatureC-C bond coupling with sp<sup>3</sup> C-H bond via active intermediates from CO<sub>2</sub> hydrogenation.PMC11697012Yang HLi GMa QFan WBitter JHLi CZhang RLi ZXie JZeng JCheng JWu XMao ZfalseC-C bond coupling with sp<sup>3</sup> C-H bond via active intermediates from CO<sub>2</sub> hydrogenation.Compared to the sluggish kinetics observed in methanol-mediated side-chain alkylation of methyl groups with sp³ C-H bonds, CO₂ hydrogenation emerges as a sustainable alternative strategy, yet it remains a challenge. Here, as far as we know, it is first reported that using CO₂ hydrogenation replacing methanol can conduct the side-chain alkylation of 4-methylpyridine (MEPY) over a binary metal oxide-zeolite Zn₄₀Zr₆₀O/CsX tandem catalyst (ZZO/CsX). This ZZO/CsX catalyst can achieve 19.6% MEPY single-pass conversion and 82% 4-ethylpyridine (ETPY) selectivity by using CO₂ hydrogenation, which is 6.5 times more active than methanol as an alkylation agent. The excellent catalytic performance is realized on the basis of the dual fun2025-01-01T00:00:00Z2025 Jan2025-04-22T09:00:40.851Z2025-04-05T22:53:19.512ZS-EPMC116970123974707710.1038/s41467-024-55640-w