{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rumfelt KE"],"funding":["Eunice Shriver National Institute for Child Health and Human Development","NICHD NIH HHS","NCATS NIH HHS","National","Women&apos;s Reproductive Health Research","Thrasher Research Fund","Center for Advancing Translational Sciences of the National Institutes of Health"],"pagination":["ofae723"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11697169"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["<h4>Background</h4>Immunization against influenza and respiratory syncytial virus (RSV) protects pregnant individuals and their infants against infection via transplacental transport of immunoglobulin G (IgG). We sought to evaluate the quantity and efficiency of maternal influenza- and RSV-specific IgG transfer in pregnancies with preterm and full-term deliveries.<h4>Methods</h4>Delivery samples from 115 maternal-infant pairs (2018-2021) were analyzed for RSV prefusion F and IAV-H3 and IAV-H1 antibodies using electrochemiluminescence assays. We used Wilcoxon rank sum tests, <i>t</i> tests, Pearson correlation coefficients (PCCs), and linear regression to evaluate distributions of IgG results by maternal influenza vaccination status and preterm birth (<37 weeks).<h4>Results</h4>Approximatel"],"journal":["Open forum infectious diseases"],"pubmed_title":["Maternal-Infant Respiratory Syncytial Virus and Influenza A Virus Antibody Transfer in Preterm and Full-term Infants."],"pmcid":["PMC11697169"],"funding_grant_id":["2 K12HD001264-21","K12 HD001264","UL1 TR002319"],"pubmed_authors":["Rumfelt KE","Stolarczuk JE","Lauring AS","Englund JA","Kachikis AB","Pike M","Lekander A","Martin ET","Eckert LO"],"additional_accession":[]},"is_claimable":false,"name":"Maternal-Infant Respiratory Syncytial Virus and Influenza A Virus Antibody Transfer in Preterm and Full-term Infants.","description":"<h4>Background</h4>Immunization against influenza and respiratory syncytial virus (RSV) protects pregnant individuals and their infants against infection via transplacental transport of immunoglobulin G (IgG). We sought to evaluate the quantity and efficiency of maternal influenza- and RSV-specific IgG transfer in pregnancies with preterm and full-term deliveries.<h4>Methods</h4>Delivery samples from 115 maternal-infant pairs (2018-2021) were analyzed for RSV prefusion F and IAV-H3 and IAV-H1 antibodies using electrochemiluminescence assays. We used Wilcoxon rank sum tests, <i>t</i> tests, Pearson correlation coefficients (PCCs), and linear regression to evaluate distributions of IgG results by maternal influenza vaccination status and preterm birth (<37 weeks).<h4>Results</h4>Approximatel","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-18T12:47:55.916Z","creation":"2025-04-03T23:27:00.901Z"},"accession":"S-EPMC11697169","cross_references":{"pubmed":["39758746"],"doi":["10.1093/ofid/ofae723"]}}