{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Odio CD"],"funding":["U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)","NIAID NIH HHS"],"pagination":["191"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11697199"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["The standard dengue virus (DENV) neutralization assay inconsistently predicts dengue protection. We compare how IgG ELISA, envelope domain III (EDIII), or non-structural protein 1 (NS1) binding antibodies, and titers from plaque reduction neutralization tests (PRNTs) using standard and mature viruses are associated with dengue. The ELISA measures IgG antibodies that bind to inactivated DENV1-4. The EDIII and NS1 assays measure binding antibodies, and the PRNTs measure neutralizing antibodies to each specific DENV serotype. Healthy children (n = 1206) in Cebu, Philippines were followed for 5 years. ELISA IgG≥3 was associated with reduced dengue probability relative to naïve children (3% vs. 10%, p = 0.007). Serotype-specific antibodies binding EDIII or NS1 had no association with dengue ris"],"journal":["Nature communications"],"pubmed_title":["Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective."],"pmcid":["PMC11697199"],"funding_grant_id":["P01AI106695","P01 AI106695"],"pubmed_authors":["Katzelnick LC","Adams C","Aogo RA","Firdous S","Ylade M","de Silva AM","Odio CD","Agrupis KA","Voirin CJ","Dahora Hein L","Abad Fernandez M","Mpingabo PI","White LJ","Crisostomo MV","Coello Escoto A","Raimundi Rodriguez G","Deen J","Daag JV"],"additional_accession":[]},"is_claimable":false,"name":"Dengue virus IgG and neutralizing antibody titers measured with standard and mature viruses are protective.","description":"The standard dengue virus (DENV) neutralization assay inconsistently predicts dengue protection. We compare how IgG ELISA, envelope domain III (EDIII), or non-structural protein 1 (NS1) binding antibodies, and titers from plaque reduction neutralization tests (PRNTs) using standard and mature viruses are associated with dengue. The ELISA measures IgG antibodies that bind to inactivated DENV1-4. The EDIII and NS1 assays measure binding antibodies, and the PRNTs measure neutralizing antibodies to each specific DENV serotype. Healthy children (n = 1206) in Cebu, Philippines were followed for 5 years. ELISA IgG≥3 was associated with reduced dengue probability relative to naïve children (3% vs. 10%, p = 0.007). Serotype-specific antibodies binding EDIII or NS1 had no association with dengue ris","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-02T02:04:52.551Z","creation":"2025-04-05T22:50:51.93Z"},"accession":"S-EPMC11697199","cross_references":{"pubmed":["39747846"],"doi":["10.1038/s41467-024-53916-9"]}}