{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iyer A"],"funding":["National Institute of Neurological Disorders and Stroke","State of Louisiana Board of Regents","Brain and Behavior Research Foundation","NINDS NIH HHS","NIH"],"pagination":["111500"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11697703"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(12)"],"pubmed_abstract":["Different neuron types develop characteristic axonal and dendritic arborizations that determine their inputs, outputs, and functions. Expression of fate-determinant transcription factors is essential for specification of their distinct identities. However, the mechanisms downstream of fate-determinant factors coordinating different aspects of neuron identity are not understood. Specifically, how distinct projection neurons develop appropriate dendritic arbors that determine their inputs is unknown. Here, we investigate this question in corticospinal and callosal projection neurons. We identified a mechanism linking the corticospinal/corticofugal identity gene <i>Fezf2</i> with the regulation of dendritic development. We show that miR-193b∼365 microRNA cluster is regulated by <i>Fezf2</i> a"],"journal":["iScience"],"pubmed_title":["miR-193b-365 microcluster downstream of &lt;i&gt;Fezf2&lt;/i&gt; coordinates neuron-subtype identity and dendritic morphology in cortical projection neurons."],"pmcid":["PMC11697703"],"funding_grant_id":["R01 NS128106"],"pubmed_authors":["Vaasjo LO","K C R","Nnebe C","Iyer A","Tharin S","Siththanandan VB","Galazo MJ","Thurmon A","Lu V","Nair R","Akumuo M"],"additional_accession":[]},"is_claimable":false,"name":"miR-193b-365 microcluster downstream of &lt;i&gt;Fezf2&lt;/i&gt; coordinates neuron-subtype identity and dendritic morphology in cortical projection neurons.","description":"Different neuron types develop characteristic axonal and dendritic arborizations that determine their inputs, outputs, and functions. Expression of fate-determinant transcription factors is essential for specification of their distinct identities. However, the mechanisms downstream of fate-determinant factors coordinating different aspects of neuron identity are not understood. Specifically, how distinct projection neurons develop appropriate dendritic arbors that determine their inputs is unknown. Here, we investigate this question in corticospinal and callosal projection neurons. We identified a mechanism linking the corticospinal/corticofugal identity gene <i>Fezf2</i> with the regulation of dendritic development. We show that miR-193b∼365 microRNA cluster is regulated by <i>Fezf2</i> a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-01T11:07:50.497Z","creation":"2026-04-08T11:42:21.503Z"},"accession":"S-EPMC11697703","cross_references":{"pubmed":["39759000"],"doi":["10.1016/j.isci.2024.111500"]}}