biostudies-literatureAtaie ZNIBIB NIH HHSNational Institutes of HealthNIH HHSNational Institute of Biomedical Imaging and Bioengineeringe2307928https://www.ebi.ac.uk/biostudies/studies/S-EPMC11699544biostudies-literatureUnknown20(8)Bulk hydrogel scaffolds are common in reconstructive surgery. They allow for the staged repair of soft tissue loss by providing a base for revascularization. Unfortunately, they are limited by both slow and random vascularization, which may manifest as treatment failure or suboptimal repair. Rapidly inducing patterned vascularization within biomaterials has profound translational implications for current clinical treatment paradigms and the scaleup of regenerative engineering platforms. To address this long-standing challenge, a novel microsurgical approach and granular hydrogel scaffold (GHS) technology are co-developed to hasten and pattern microvascular network formation. In surgical micropuncture (MP), targeted recipient blood vessels are perforated using a microneedle to accelerate ceSmall (Weinheim an der Bergstrasse, Germany)Accelerating Patterned Vascularization Using Granular Hydrogel Scaffolds and Surgical Micropuncture.PMC11699544R56EB032672R56 EB032672Horchler SJaberi ASun MRisbud ARavnic DJSilva ARAEKheirabadi SSheikhi AEl-Mallah JCKoduru SVAtaie ZKedzierski AfalseAccelerating Patterned Vascularization Using Granular Hydrogel Scaffolds and Surgical Micropuncture.Bulk hydrogel scaffolds are common in reconstructive surgery. They allow for the staged repair of soft tissue loss by providing a base for revascularization. Unfortunately, they are limited by both slow and random vascularization, which may manifest as treatment failure or suboptimal repair. Rapidly inducing patterned vascularization within biomaterials has profound translational implications for current clinical treatment paradigms and the scaleup of regenerative engineering platforms. To address this long-standing challenge, a novel microsurgical approach and granular hydrogel scaffold (GHS) technology are co-developed to hasten and pattern microvascular network formation. In surgical micropuncture (MP), targeted recipient blood vessels are perforated using a microneedle to accelerate ce2024-01-01T00:00:00Z2024 Feb2025-04-05T10:18:26.646Z2025-04-05T10:18:26.646ZS-EPMC116995443782428010.1002/smll.202307928