biostudies-literatureKyoda KNational Bioscience Database CenterCore Research for Evolutional Science and TechnologyRIKEN Center for Biosystems Dynamics ResearchEuropean UnionJapan Society for the Promotion of ScienceD1716-D1723https://www.ebi.ac.uk/biostudies/studies/S-EPMC11701685biostudies-literatureUnknown53(D1)SSBD (https://ssbd.riken.jp) is a platform for the sharing and reuse of bioimaging data. As part of efforts to build a bioimaging data ecosystem, SSBD has recently been updated to a two-tiered data resource comprising SSBD:repository, a public repository for the sharing of all types of bioimaging data reported in journals, and SSBD:database, an added-value database for the sharing of curated, highly reusable, metadata-rich data. This update addresses the conflicting demands of rapid data publication and sharing of richly annotated data, thereby promoting bioimaging data sharing and reuse. With this update, SSBD is now positioned as a core repository and database within the foundingGIDE, an international consortium working to establish a global image data ecosystem. Harmonizing metadata betNucleic acids researchSSBD: an ecosystem for enhanced sharing and reuse of bioimaging data.PMC11701685JPMJCR1511JPMJCR1926JP18H05412101130216JP22H04926JPMJND2201Kyoda KItoga HYamamoto HMiranda-Miranda MTohsato YFujisawa EWang FNakano YOnami SYamagata YfalseSSBD: an ecosystem for enhanced sharing and reuse of bioimaging data.SSBD (https://ssbd.riken.jp) is a platform for the sharing and reuse of bioimaging data. As part of efforts to build a bioimaging data ecosystem, SSBD has recently been updated to a two-tiered data resource comprising SSBD:repository, a public repository for the sharing of all types of bioimaging data reported in journals, and SSBD:database, an added-value database for the sharing of curated, highly reusable, metadata-rich data. This update addresses the conflicting demands of rapid data publication and sharing of richly annotated data, thereby promoting bioimaging data sharing and reuse. With this update, SSBD is now positioned as a core repository and database within the foundingGIDE, an international consortium working to establish a global image data ecosystem. Harmonizing metadata bet2025-01-01T00:00:00Z2025 Jan2026-04-08T19:09:04.97Z2026-04-08T11:41:08.636ZS-EPMC117016853947978110.1093/nar/gkae860