biostudies-literatureUnknownChadourne MNCI NIH HHSThousands of regulatory noncoding RNAs (ncRNAs) have been annotated; however, their functions in gene regulation and contributions to cancer formation remain poorly understood. To gain a better understanding of the influence of ncRNAs on gene regulation during melanoma progression, we mapped the landscape of ncRNAs in melanocytes and melanoma cells. Nearly half of deregulated genes in melanoma are ncRNAs, with antisense RNAs (asRNAs) comprising a large portion of deregulated ncRNAs. <i>CDH3-AS1</i>, the most significantly downregulated asRNA, overlaps the <i>CDH3</i> gene, which encodes P-cadherin, a transmembrane glycoprotein involved in cell adhesion that was also reduced in melanoma. Overexpression of <i>CDH3-AS1</i> increased cell aggregation and reduced xenograft tumor growth, mimickibioRxiv : the preprint server for biology2024.12.26.630428https://www.ebi.ac.uk/biostudies/studies/S-EPMC11703152biostudies-literatureCDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma.PMC11703152R01 CA259046P30 CA076292Chadourne MJaeger AMKarreth FABrennan EVera OGriffith CXu XMecozzi NWang KfalseCDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma.Thousands of regulatory noncoding RNAs (ncRNAs) have been annotated; however, their functions in gene regulation and contributions to cancer formation remain poorly understood. To gain a better understanding of the influence of ncRNAs on gene regulation during melanoma progression, we mapped the landscape of ncRNAs in melanocytes and melanoma cells. Nearly half of deregulated genes in melanoma are ncRNAs, with antisense RNAs (asRNAs) comprising a large portion of deregulated ncRNAs. <i>CDH3-AS1</i>, the most significantly downregulated asRNA, overlaps the <i>CDH3</i> gene, which encodes P-cadherin, a transmembrane glycoprotein involved in cell adhesion that was also reduced in melanoma. Overexpression of <i>CDH3-AS1</i> increased cell aggregation and reduced xenograft tumor growth, mimicki2024-01-01T00:00:00Z2024 Dec2026-05-05T03:20:32.961Z2026-05-05T03:13:08.7ZS-EPMC117031523976405510.1101/2024.12.26.630428