{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cheng E"],"funding":["Natural Sciences and Engineering Research Council of Canada","Fonds de recherche du Québec – Nature et technologies","NIH HHS"],"pagination":["e1011351"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11706408"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(12)"],"pubmed_abstract":["Stem and progenitor cell mitosis is essential for tissue development and homeostasis. How these cells ensure proper chromosome segregation, and thereby maintain mitotic fidelity, in the complex physiological environment of a living animal is poorly understood. Here we use in situ live-cell imaging of C. elegans germline stem and progenitor cells (GSPCs) to ask how the signaling environment influences stem and progenitor cell mitosis in vivo. Through a candidate screen we identify a new role for the insulin/IGF receptor (IGFR), daf-2, during GSPC mitosis. Mitosis is delayed in daf-2/IGFR mutants, and these delays require canonical, DAF-2/IGFR to DAF-16/FoxO insulin signaling, here acting cell non-autonomously from the soma. Interestingly, mitotic delays in daf-2/IGFR mutants depend on the s"],"journal":["PLoS genetics"],"pubmed_title":["Non-autonomous insulin signaling delays mitotic progression in C. elegans germline stem and progenitor cells."],"pmcid":["PMC11706408"],"funding_grant_id":["RGPIN/05199-2020","P40 OD010440","283252"],"pubmed_authors":["Cheng E","Gerhold AR","Lu R"],"additional_accession":[]},"is_claimable":false,"name":"Non-autonomous insulin signaling delays mitotic progression in C. elegans germline stem and progenitor cells.","description":"Stem and progenitor cell mitosis is essential for tissue development and homeostasis. How these cells ensure proper chromosome segregation, and thereby maintain mitotic fidelity, in the complex physiological environment of a living animal is poorly understood. Here we use in situ live-cell imaging of C. elegans germline stem and progenitor cells (GSPCs) to ask how the signaling environment influences stem and progenitor cell mitosis in vivo. Through a candidate screen we identify a new role for the insulin/IGF receptor (IGFR), daf-2, during GSPC mitosis. Mitosis is delayed in daf-2/IGFR mutants, and these delays require canonical, DAF-2/IGFR to DAF-16/FoxO insulin signaling, here acting cell non-autonomously from the soma. Interestingly, mitotic delays in daf-2/IGFR mutants depend on the s","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-05-29T15:22:52.544Z","creation":"2025-04-04T21:49:29.543Z"},"accession":"S-EPMC11706408","cross_references":{"pubmed":["39715269"],"doi":["10.1371/journal.pgen.1011351"]}}